Synchronous colorectal liver metastases: focus on the elderly

Synchronous colorectal liver metastases: focus on the elderly Langenbecks Arch Surg (2017) 402:1223–1232 DOI 10.1007/s00423-017-1611-8 ORIGINAL ARTICLE An Effectiveness Study from Routine Care 1 1 1 2 Markus Albertsmeier & Andrea Engel & Markus O. Guba & Sebastian Stintzing & 1 3 3 1 Tobias S. Schiergens & Gabriele Schubert-Fritschle & Dieter Hölzel & Jens Werner & 1 3 Martin K. Angele & Jutta Engel Received: 8 January 2017 /Accepted: 20 July 2017 /Published online: 12 August 2017 Springer-Verlag GmbH Germany 2017 Abstract lower compared to younger patients (OS 34.3 vs. 43.5%, Purpose The goal of this study was to analyze the use and the P = 0.0114). In a Cox regression model, complete surgical effectiveness of both surgery and different chemotherapies in removal of liver metastases was the most effective treatment patients with synchronous colorectal liver metastases (CLMs) (HR 0.313, P < 0.001) followed by chemotherapy (irinotecan/ ≥70 years compared to younger patients. platin-based: HR 0.371, 5-FU only: HR 0.673, P <0.001). Methods Survival was analyzed in 456 patients (24.3% Having >5 liver metastases, the presence of extrahepatic metas- ≥70 years) treated for CLM in a single center using Kaplan- tases, high grading, and a nodal positive primary but not age Meier estimation of overall survival Langenbeck's Archives of Surgery Springer Journals

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Springer Berlin Heidelberg
Copyright © 2017 by Springer-Verlag GmbH Germany
Medicine & Public Health; General Surgery; Abdominal Surgery; Cardiac Surgery; Thoracic Surgery; Traumatic Surgery; Vascular Surgery
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