Sweet Strategies in Prostate Cancer Biomarker Research: Focus on a Prostate Specific Antigen

Sweet Strategies in Prostate Cancer Biomarker Research: Focus on a Prostate Specific Antigen A clarion call for early diagnosis of prostate cancer (PCa) can be addressed using new strategies such as aberrant protein glycosylation. Proteins are naturally affected by numerous post-translational modifications, mainly by glycosylation which is associated with physiological and pathological transformation participating in the development of diseases such as various types of cancer, but also neurodegenerative disorders, endocrine abnormalities, AIDS, etc. Therefore, glycoproteins play crucial role in cancer biomarker research and determination of glycosylation is nowadays one of the key analytical tasks. Predominantly used approach based on affinity assays using lectins as glycorecognition elements has become an essential part in the biomedical research with great prospects in the clinical diagnostics. Owing to their ability to specifically recognize saccharide structures, lectins can be applied for binding to different molecules and substrates such as proteins, lipids, cell walls as well as in biological materials, including stem cells and microorganisms. In order to improve the diagnostic potential of well-known cancer biomarkers, lectin-based biosensors and biochips are already being widely used for the detection of glycoproteins. In this review, we will focus on various bioassay strategies for glycoprofiling of a prostate-specific antigen (PSA) with emphasis to modern and prospective techniques suitable for analysis of PSA glycan motifs as biosensors, biochips and mass spectrometry methods. All mentioned methods are suitable for applications in research, diagnosis and therapy of PCa. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png BioNanoScience Springer Journals

Sweet Strategies in Prostate Cancer Biomarker Research: Focus on a Prostate Specific Antigen

11 pages
Read Article

Loading next page...
 
/lp/springer_journal/sweet-strategies-in-prostate-cancer-biomarker-research-focus-on-a-lP6zhibS9b
Publisher
Springer Journals
Copyright
Copyright © 2017 by Springer Science+Business Media New York
Subject
Engineering; Circuits and Systems; Biological and Medical Physics, Biophysics; Nanotechnology; Biomaterials
ISSN
2191-1630
eISSN
2191-1649
DOI
10.1007/s12668-017-0397-z
Publisher site
See Article on Publisher Site

Abstract

A clarion call for early diagnosis of prostate cancer (PCa) can be addressed using new strategies such as aberrant protein glycosylation. Proteins are naturally affected by numerous post-translational modifications, mainly by glycosylation which is associated with physiological and pathological transformation participating in the development of diseases such as various types of cancer, but also neurodegenerative disorders, endocrine abnormalities, AIDS, etc. Therefore, glycoproteins play crucial role in cancer biomarker research and determination of glycosylation is nowadays one of the key analytical tasks. Predominantly used approach based on affinity assays using lectins as glycorecognition elements has become an essential part in the biomedical research with great prospects in the clinical diagnostics. Owing to their ability to specifically recognize saccharide structures, lectins can be applied for binding to different molecules and substrates such as proteins, lipids, cell walls as well as in biological materials, including stem cells and microorganisms. In order to improve the diagnostic potential of well-known cancer biomarkers, lectin-based biosensors and biochips are already being widely used for the detection of glycoproteins. In this review, we will focus on various bioassay strategies for glycoprofiling of a prostate-specific antigen (PSA) with emphasis to modern and prospective techniques suitable for analysis of PSA glycan motifs as biosensors, biochips and mass spectrometry methods. All mentioned methods are suitable for applications in research, diagnosis and therapy of PCa.

Journal

BioNanoScience – Springer Journals

Published: Feb 23, 2017

References

  • Cancer statistics, 2013
    Siegel, R; Naishadham, D; Jemal, A
  • Novel diagnostic biomarkers for prostate cancer
    Madu, CO; Lu, Y
  • Prostate cancer originating in basal cells progresses to adenocarcinoma propagated by luminal-like cells
    Stoyanova, T; Cooper, AR; Drake, JM; Liu, X; Armstrong, AJ; Pienta, KJ; Zhang, H; Kohn, DB; Huang, J; Witte, ON; Goldstein, AS
  • Patient-reported symptoms after primary therapy for early prostate cancer: results of a prospective cohort study
    Talcott, JA; Rieker, P; Clark, JA; Propert, KJ; Weeks, JC; Beard, CJ; Wishnow, KI; Kaplan, I; Loughlin, KR; Richie, JP; Kantoff, PW
  • Recent advances in bone-targeted therapies of metastatic prostate cancer
    Deng, X; He, G; Liu, J; Luo, F; Peng, X; Tang, S; Gao, Z; Lin, Q; Keller, JM; Yang, T; Keller, ET
  • Arraying the post-translational glycoproteome (PTG)
    Blixt, O; Westerlind, U
  • Alterations in glycosylation as biomarkers for cancer detection
    Reis, CA; Osorio, H; Silva, L; Gomes, C; David, L
  • The role of glycans in the development and progression of prostate cancer
    Munkley, J; Mills, IG; Elliott, DJ
  • Glycan and lectin biosensors
    Belický, Š; Katrlík, J; Tkáč, J
  • Electrochemistry of nonconjugated proteins and glycoproteins. Toward sensors for biomedicine and glycomics
    Paleček, E; Tkáč, J; Bartošík, M; Bertók, T; Ostatná, V; Paleček, J
  • Incidence of the blood groups and the secretor factor in patients with pernicious anemia and stomach carcinoma
    Ladenson, RP; Schwartz, SO; Ivy, AC
  • Glycolipids of hamster fibroblasts and derived malignant-transformed cell lines
    Hakomori, SI; Murakami, WT
  • How do gangliosides regulate RTKs signaling?
    Julien, S; Bobowski, M; Steenackers, A; Le Bourhis, X; Delannoy, P
  • The sweet and sour of serological glycoprotein tumor biomarker quantification
    Kuzmanov, U; Kosanam, H; Diamandis, E
  • Essentials of glycobiology
    Varki, A
  • Aberrant PSA glycosylation—a sweet predictor of prostate cancer
    Gilgunn, S; Conroy, PJ; Saldova, R; Rudd, PM; O'Kennedy, RJ
  • Cancer biomarker discovery: lectin-based strategies targeting glycoproteins
    Clark, D; Mao, L
  • Control of mucin-type O-glycosylation: a classification of the polypeptide GalNAc-transferase gene family
    Bennett, EP; Mandel, U; Clausen, H; Gerken, TA; Fritz, TA; Tabak, LA
  • Analysis of protein glycosylation by mass spectrometry
    Morelle, W; Michalski, J-C
  • Analysis of serum protein glycosylation with antibody-lectin microarray for high-throughput biomarker screening
    Li, C; Lubman, D
  • Sweet characterisation of prostate specific antigen using electrochemical lectin-based immunosensor assay and MALDI TOF/TOF analysis: focus on sialic acid
    Pihikova, D; Pakanova, Z; Nemcovic, M; Barath, P; Belicky, S; Bertok, T; Kasak, P; Mucha, J; Tkac, J
  • Exploiting lectin affinity chromatography in clinical diagnosis
    Satish, PR; Surolia, A
  • Glycan and lectin microarrays for glycomics and medicinal applications
    Katrlik, J; Svitel, J; Gemeiner, P; Kozar, T; Tkac, J
  • Lectin-based lateral flow assay: proof-of-concept
    Damborsky, P; Koczula, KM; Gallotta, A; Katrlik, J
  • Other biomarkers for detecting prostate cancer
    Nogueira, L; Corradi, R; Eastham, JA
  • Prostate cancer biomarkers: an update
    Romero Otero, J; Garcia Gomez, B; Campos Juanatey, F; Touijer, KA
  • Risk stratification in prostate cancer screening
    Roobol, MJ; Carlsson, SV
  • Screening and prostate-cancer mortality in a randomized European study
    Schröder, FH; Hugosson, J; Roobol, MJ; Tammela, TLJ; Ciatto, S; Nelen, V; Kwiatkowski, M; Lujan, M; Lilja, H; Zappa, M; Denis, LJ; Recker, F; Berenguer, A; Määttänen, L; Bangma, CH; Aus, G; Villers, A; Rebillard, X; Kwast, T; Blijenberg, BG; Moss, SM; Koning, HJ; Auvinen, A
  • Glycosylation of prostate specific antigen and its potential diagnostic applications
    Vermassen, T; Speeckaert, MM; Lumen, N; Rottey, S; Delanghe, JR
  • Clinical impact of prostate specific antigen (PSA) inter-assay variability on management of prostate cancer
    Murthy, V; Rishi, A; Gupta, S; Kannan, S; Mahantshetty, U; Tongaonkar, H; Bakshi, G; Prabhash, K; Bhanushali, P; Shinde, B; Inamdar, N; Shrivastava, S
  • Altered glycosylation pattern allows the distinction between prostate-specific antigen (PSA) from normal and tumor origins
    Peracaula, R; Tabares, G; Royle, L; Harvey, DJ; Dwek, RA; Rudd, PM; Llorens, R
  • Improvement of prostate cancer diagnosis by detecting PSA glycosylation-specific changes
    Llop, E; Ferrer-Batallé, M; Barrabés, S; Guerrero, PE; Ramírez, M; Saldova, R; Rudd, PM; Aleixandre, RN; Comet, J; Llorens, R; Peracaula, R
  • Affinity analysis of lectin interaction with immobilized C- and O- gylcosides studied by surface plasmon resonance assay
    Nahalkova, J; Svitel, J; Gemeiner, P; Danielsson, B; Pribulova, B; Petrus, L
  • Lectins as tools in glycoconjugate research
    Wu, AM; Lisowska, E; Duk, M; Yang, Z
  • SPR studies of carbohydrate-lectin interactions as useful tool for screening on lectin sources
    Vornholt, W; Hartmann, M; Keusgen, M
  • Carbohydrate structure and differential binding of prostate specific antigen to Maackia amurensis lectin between prostate cancer and benign prostate hypertrophy
    Ohyama, C; Hosono, M; Nitta, K; Oh-eda, M; Yoshikawa, K; Habuchi, T; Arai, Y; Fukuda, M
  • Sialylation and fucosylation of cancer-associated prostate specific antigen
    Kosanovic, MM; Jankovic, MM
  • Glycoproteomics for prostate cancer detection: changes in serum PSA glycosylation patterns
    Meany, D; Zhang, Z; Sokoll, L; Zhang, H; Chan, D
  • Alpha 1, 2-fucosylated and beta-N-acetylgalactosaminylated prostate-specific antigen as an efficient marker of prostatic cancer
    Fukushima, K; Satoh, T; Baba, S; Yamashita, K
  • A sensitive assay to measure biomarker glycosylation demonstrates increased fucosylation of prostate specific antigen (PSA) in patients with prostate cancer compared with benign prostatic hyperplasia
    Dwek, MV; Jenks, A; Leathem, AJ
  • Enzyme-linked lectin assay (ELLA): use of alkaline phosphatase-conjugated Griffonia simplicifolia B4 isolectin for the detection of alpha-D-galactopyranosyl end groups
    McCoy, J; Varani, J; Goldstein, I
  • A sensitive assay to measure biomarker glycosylation demonstrates increased fucosylation of prostate specific antigen (PSA) in patients with prostate cancer compared with benign prostatic hyperplasia
    Dwek, M; Jenks, A; Leathem, A
  • Serum fucosylated prostate-specific antigen (PSA) improves the differentiation of aggressive from non-aggressive prostate cancers
    Li, QK; Chen, L; Ao, MH; Chiu, JH; Zhang, Z; Zhang, H; Chan, DW
  • Concanavalin A immobilized magnetic poly (glycidyl methacrylate) beads for prostate specific antigen binding
    Idil, N; Perçin, I; Karakoç, V; Yavuz, H; Aksöz, N; Denizli, A
  • Measurement of aberrant glycosylation of prostate specific antigen can improve specificity in early detection of prostate cancer
    Yoneyama, T; Ohyama, C; Hatakeyama, S; Narita, S; Habuchi, T; Koie, T; Mori, K; Hidari, KI; Yamaguchi, M; Suzuki, T; Tobisawa, Y
  • Aberrant sialylation of a prostate-specific antigen: electrochemical label-free glycoprofiling in prostate cancer serum samples
    Pihikova, D; Kasak, P; Kubanikova, P; Sokol, R; Tkac, J
  • DNA aptamer-based sandwich microfluidic assays for dual quantification and multi-glycan profiling of cancer biomarkers
    Jolly, P; Damborsky, P; Madaboosi, N; Soares, RR; Chu, V; Conde, JP; Katrlik, J; Estrela, P
  • The origins and the future of microfluidics
    Whitesides, GM
  • Recent developments in paper-based microfluidic devices
    Cate, DM; Adkins, JA; Mettakoonpitak, J; Henry, CS
  • Paper-based microfluidic point-of-care diagnostic devices
    Yetisen, AK; Akram, MS; Lowe, CR
  • Simultaneous concentration and detection of biomarkers on paper
    Chiu, RYT; Jue, E; Yip, AT; Berg, AR; Wang, SJ; Kivnick, AR; Nguyen, PT; Kamei, DT
  • An integrated paper-based sample-to-answer biosensor for nucleic acid testing at the point of care
    Choi, JR; Hu, J; Tang, R; Gong, Y; Feng, S; Ren, H; Wen, T; Li, X; Wan Abas, WAB; Pingguan-Murphy, B; Xu, F
  • Determining the binding affinities of prostate-specific antigen to lectins: SPR and microarray approaches
    Damborsky, P; Zamorova, M; Katrlik, J
  • Electrode systems for continuous monitoring in cardiovascular surgery
    Clark, LC; Lyons, C
  • Electrochemical biosensors and nanobiosensors
    Hammond, J; Formisano, N; Estrela, P; Carrara, S; Tkac, J
  • Electrochemical biosensors-sensor principles and architectures
    Grieshaber, D; MacKenzie, R; Vörös, J; Reimhult, E
  • Sensitive detection and glycoprofiling of a prostate specific antigen using impedimetric assays
    Pihikova, D; Belicky, S; Kasak, P; Bertok, T; Tkac, J
  • Sandwich-type electrochemical biosensor for glycoproteins detection based on dual-amplification of boronic acid-gold nanoparticles and dopamine-gold nanoparticles
    Xia, N; Deng, D; Zhang, L; Yuan, B; Jing, M; Du, J; Liu, L
  • Label-free ultrasensitive memristive aptasensor
    Tzouvadaki, I; Jolly, P; Lu, X; Ingebrandt, S; De Micheli, G; Estrela, P; Carrara, S
  • Molecularly imprinted polymers and their use in biomimetic sensors
    Haupt, K; Mosbach, K
  • Aptamer–MIP hybrid receptor for highly sensitive electrochemical detection of prostate specific antigen
    Jolly, P; Tamboli, V; Harniman, RL; Estrela, P; Allender, CJ; Bowen, JL
  • Aptasensors—the future of biosensing?
    O'Sullivan, C
  • Electrochemical sensing of concanavalin A and ovalbumin interaction in solution
    Vargová, V; Helma, R; Paleček, E; Ostatná, V
  • High-sensitivity analytical approaches for the structural characterization of glycoproteins
    Alley, WR; Mann, BF; Novotny, MV
  • Chip-based reversed-phase liquid chromatography−mass spectrometry of permethylated N-linked glycans: a potential methodology for cancer-biomarker discovery
    Alley, WR; Madera, M; Mechref, Y; Novotny, MV
  • Glycomic analysis of human respiratory tract tissues and correlation with influenza virus infection
    Walther, T; Karamanska, R; Chan, RW; Chan, MC; Jia, N; Air, G; Hopton, C; Wong, MP; Dell, A; Peiris, JM
  • Analysis of immunoglobulin glycosylation by LC-ESI-MS of glycopeptides and oligosaccharides
    Stadlmann, J; Pabst, M; Kolarich, D; Kunert, R; Altmann, F
  • ICP-MS-based multiplex profiling of glycoproteins using lectins conjugated to lanthanide-chelating polymers
    Leipold, MD; Herrera, I; Ornatsky, O; Baranov, V; Nitz, M
  • Liquid chromatography/mass spectrometry sequencing approach for highly sulfated heparin-derived oligosaccharides
    Thanawiroon, C; Rice, KG; Toida, T; Linhardt, RJ
  • Negative ion graphitised carbon nano-liquid chromatography/mass spectrometry increases sensitivity for glycoprotein oligosaccharide analysis
    Karlsson, NG; Wilson, NL; Wirth, HJ; Dawes, P; Joshi, H; Packer, NH
  • Protein glycosylation analyzed by normal-phase nano-liquid chromatography–mass spectrometry of glycopeptides
    Wuhrer, M; Koeleman, CA; Hokke, CH; Deelder, AM
  • Integration of the transcriptome and glycome for identification of glycan cell signatures
    Bennun, SV; Yarema, KJ; Betenbaugh, MJ; Krambeck, FJ
  • Glycoproteomics: identifying the glycosylation of prostate specific antigen at normal and high isoelectric points by LC–MS/MS
    Song, E; Mayampurath, A; Yu, C-Y; Tang, H; Mechref, Y
  • Interlaboratory study on differential analysis of protein glycosylation by mass spectrometry: the ABRF glycoprotein research multi-institutional study 2012
    Leymarie, N; Griffin, PJ; Jonscher, K; Kolarich, D; Orlando, R; McComb, M; Zaia, J; Aguilan, J; Alley, WR; Altmann, F; Ball, LE; Basumallick, L; Bazemore-Walker, CR; Behnken, H; Blank, MA; Brown, KJ; Bunz, SC; Cairo, CW; Cipollo, JF; Daneshfar, R; Desaire, H; Drake, RR; Go, EP; Goldman, R; Gruber, C; Halim, A; Hathout, Y; Hensbergen, PJ; Horn, DM; Hurum, D; Jabs, W; Larson, G; Ly, M; Mann, BF; Marx, K; Mechref, Y; Meyer, B; Moginger, U; Neusubeta, C; Nilsson, J; Novotny, MV; Nyalwidhe, JO; Packer, NH; Pompach, P; Reiz, B; Resemann, A; Rohrer, JS; Ruthenbeck, A; Sanda, M; Schulz, JM; Schweiger-Hufnagel, U; Sihlbom, C; Song, E; Staples, GO; Suckau, D; Tang, H; Thaysen-Andersen, M; Viner, RI; An, Y; Valmu, L; Wada, Y; Watson, M; Windwarder, M; Whittal, R; Wuhrer, M; Zhu, Y; Zou, C
  • Glycan analysis of prostate specific antigen (PSA) directly from the intact glycoprotein by HR-ESI/TOF-MS
    Behnken, HN; Ruthenbeck, A; Schulz, J-M; Meyer, B
  • Characterization of the glycosylation site of human PSA prompted by missense mutation using LC-MS/MS
    Song, E; Hu, Y; Hussein, A; Yu, CY; Tang, H; Mechref, Y
  • Glycomic analysis of sialic acid linkages in glycans derived from blood serum glycoproteins
    Alley, WR; Novotny, MV
  • Determination of the sialylation level and of the ratio alpha-(2-->3)/alpha-(2-->6) sialyl linkages of N-glycans by methylation and GC/MS analysis
    Cointe, D; Leroy, Y; Chirat, F
  • High-throughput profiling of protein N-glycosylation by MALDI-TOF-MS employing linkage-specific sialic acid esterification
    Reiding, KR; Blank, D; Kuijper, DM; Deelder, AM; Wuhrer, M
  • Linkage-specific sialic acid derivatization for MALDI-TOF-MS profiling of IgG glycopeptides
    Haan, N; Reiding, KR; Haberger, M; Reusch, D; Falck, D; Wuhrer, M
  • Comparative ESI FT-MS and MALDI-TOF structural analyses of representative human N-linked glycans
    Pakanová, Z; Nemčovič, M; Bystrický, P; Matulová, M; Pätoprstý, V; Wilson Iain, BH; Mucha, J
  • Structural characteristics of the N-glycans of two isoforms of prostate-specific antigens purified from human seminal fluid
    Okada, T; Sato, Y; Kobayashi, N; Sumida, K; Satomura, S; Matsuura, S; Takasaki, M; Endo, T
  • Glycomic characterization of prostate-specific antigen and prostatic acid phosphatase in prostate cancer and benign disease seminal plasma fluids
    White, KY; Rodemich, L; Nyalwidhe, JO; Comunale, MA; Clements, MA; Lance, RS; Schellhammer, PF; Mehta, AS; Semmes, OJ; Drake, RR
  • Oligosaccharide profiles of the prostate specific antigen in free and complexed forms from the prostate cancer patient serum and in seminal plasma: a glycopeptide approach
    Tajiri, M; Ohyama, C; Wada, Y
  • Glycan characterization of PSA 2-DE subforms from serum and seminal plasma
    Sarrats, A; Saldova, R; Comet, J; O'Donoghue, N; Llorens, R; Rudd, PM; Peracaula, R
  • Simultaneous analysis of glycosylated and sialylated PSA reveals differential distribution of glycosylated PSA isoforms in prostate cancer tissues
    Li, Y; Tian, Y; Rezai, T; Prakash, A; Lopez, MF; Chan, DW; Zhang, H
  • Analysis of urinary prostate-specific antigen glycoforms in samples of prostate cancer and benign prostate hyperplasia
    Hsiao, C-J; Tzai, T-S; Chen, C-H; Yang, W-H; Chen, C-H
  • Development and validation of a quantitative ELISA for the measurement of PSA concentration
    Acevedo, B; Perera, Y; Ruiz, M; Rojas, G; Benítez, J; Ayala, M; Gavilondo, J

You’re reading a free preview. Subscribe to read the entire article.

Try 2 weeks free now

DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

or browse the journals available

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create folders to
organize your research

Export folders, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off

Sign up
for free
Start 14 day
Free Trial