J. Membrane Biol. 177, 95–108 (2000) The Journal of DOI: 10.1007/s002320001103 Membrane Biology © Springer-Verlag New York Inc. 2000 Topical Review R.J. Wilkins, J.A. Browning, J.C. Ellory University Laboratory of Physiology, Parks Road, Oxford, OX1 3PT, UK Received: 13 April 2000/Revised: 21 June 2000 Introduction rity of the extracellular matrix by balancing macromo- lecular synthesis with breakdown . The matrix that The separation of the extracellular milieu from the cyto- surrounds them confers a mechanically resilient surface sol is especially important for articular chondrocytes, to the articulating bones within joints, and comprises given the atypical and arguably challenging environment collagens (principally collagen II), other noncollagenous that these cells inhabit [77, 110, 117]. Chondrocytes, proteins, and proteoglycans (Fig. 1) . There have like all other cells, must possess effective membrane been many surveys of the biochemistry of articular car- transport systems to minimize changes of cellular com- tilage [for example, 14, 26, 58, 88] and a detailed con- position in the face of fluctuating surroundings [53, 82, sideration of these individual components is beyond the 108]. They must also scavenge adequate precursor mol- scope of this review. Here, it is sufficient to note that the ecules for matrix macromolecule synthesis,
The Journal of Membrane Biology – Springer Journals
Published: Sep 15, 2000
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