Russian Journal of Applied Chemistry, 2009, Vol. 82, No. 4, pp. 680−684.
Pleiades Publishing, Ltd., 2009.
Original Russian Text
O.V. Gornukhina, I.A. Vershinina, O.A. Golubchikov, 2009, published in Zhurnal Prikladnoi Khimii, 2009, Vol. 82, No. 4, pp. 683−687.
AND POLYMERIC MATERIALS
Surface Modiﬁ cation of Polypropilene by Gentamicin
O. V. Gornukhina, I. A. Vershinina, and O. A. Golubchikov
Ivanovo State Chemical-Thechnological University, Ivanovo, Russia
Institute of Chemistry of Solutions, Russian Academy of Science, Ivanovo, Russia
Received October 17, 2008
Abstract—A possibility of the immobilization of gentamicin on the surface of the polypropylene materials activated
by the aqueous solution of hydrogen peroxide is studied. The polymers modified by biologically active materials
are mainly the polymers of medical designation. Their basic function is exerting a complex of therapeutic actions
in all phases (inflammation, regeneration and epitalization). Such materials in essence are used for preparing
surgical seam threads, ambulance means, fixing bandages, prostheses of internal organs and tissues, etc.
The scope of medicines for admitting the biological
(in particular, bactericidal) activity to polymer carriers
is quite limited. Such means should be searched ﬁ rst of
all among the chemotherapeutic preparations, antibiotics
and antiseptics. One group of this type of preparations
Polypropylene (PP) is characterized by high
mechanical durability and chemical stability, and it can
be used as the medical material of the multifunctional
action: as structural and shielding material and as
a carrier and a donor of therapeutic and preventive
pharmacological means. However owing to its inertness
it requires the surface activation by applying chemical
reagents, which leads to formation on the surface and in
the thin near-surface layer of the polymer of the required
functional groups practically without a change in the
volumetric and strength properties of the initial material.
This form of surface activation makes it possible grafting
the medicinal substances bearing active functional groups
on the periphery of bioactive molecules to the polymer
The strength of the binding antimicrobial substances
on the polymer carrier can be regulated by the inclusion
of the corresponding functional groups in polymer and
medicines. Thus, it is possible the creation of the materials
with prolonged action that most actual now [1−3].
The purpose of this work was the surface modiﬁ cation
of polypropylene with gentamicin and creation on
this basis of the materials of medical designation.
The activation of the polypropylene surface for the
immobilization of gentamicin was conducted by action
of aqueous solution of hydrogen peroxide.
The work up by the solution of hydrogen peroxide
in the presence of Fe(II) salts is effective enough for the
activation of the polymer surface.
In the work were used the films of isotactic
polypropylene with thickness of 20 μ (biaxially oriented)
and non-woven polypropylene material of the type
“Spanbond” with speciﬁ c density 40 g m
The surface activation of polypropylene materials
was carried out by the following procedure. The samples
of PP with the area of 20 × 65 mm
were placed into
the weighing bottles with the 37% aqueous solution of
hydrogen peroxide, and two drops of the aqueous solution
of iron(II) sulfate was added. Then weighing bottles
were kept in a thermostate at 60°C for 2-h activation
duration. At the end of the activation the weighing bottle
were taken from the thermostat and cooled in air to room
The chemical composition of the surface layer of the
initial and the activated PP was investigated by the method
of infrared spectroscopy in the version of repeatedly
disrupted total internal reﬂ ection (MIR). Measurements