Surface microdeformations and regulation of cell movements in Xenopus development

Surface microdeformations and regulation of cell movements in Xenopus development The velocities and directions of movements of individual outer ectodermal cells of Xenopus embryos in the course of normal development from the blastula to the early tail-bud stage, as well as after mechanical relaxation in the early gastrula, were measured. An alternation of the periods of directed movements of large cell masses and local cell wanderings was detected. In both cases, the trajectories of individual cells consisted primarily of orthogonal segments. Cell movements were measured on two scales. At a smallscale consideration (time intervals of the order of several hours and distances of the order of tens of microns), fairly slight linear stretching and compressive deformations were detected, which looked like gentle smooth gradients along which the upward morphogenetic movements of cells were directed. At a large-scale consideration (time intervals of the order of tens of minutes and distances of the order of microns), quasi-periodic fluctuations of velocities of individual cells partly correlated in time were found. The differences between these velocities generated microdeformations, which reached several tens of percent and developed within time intervals not more than 10 min. Measurements of relative magnitudes of mechanical forces influencing the cell walls suggests that microdeformations generate local stretching and compressive deformations modulating smoother tension gradients. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Russian Journal of Developmental Biology Springer Journals

Surface microdeformations and regulation of cell movements in Xenopus development

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Publisher
Pleiades Publishing
Copyright
Copyright © 2016 by Pleiades Publishing, Inc.
Subject
Life Sciences; Developmental Biology; Animal Anatomy / Morphology / Histology
ISSN
1062-3604
eISSN
1608-3326
D.O.I.
10.1134/S1062360416010045
Publisher site
See Article on Publisher Site

Abstract

The velocities and directions of movements of individual outer ectodermal cells of Xenopus embryos in the course of normal development from the blastula to the early tail-bud stage, as well as after mechanical relaxation in the early gastrula, were measured. An alternation of the periods of directed movements of large cell masses and local cell wanderings was detected. In both cases, the trajectories of individual cells consisted primarily of orthogonal segments. Cell movements were measured on two scales. At a smallscale consideration (time intervals of the order of several hours and distances of the order of tens of microns), fairly slight linear stretching and compressive deformations were detected, which looked like gentle smooth gradients along which the upward morphogenetic movements of cells were directed. At a large-scale consideration (time intervals of the order of tens of minutes and distances of the order of microns), quasi-periodic fluctuations of velocities of individual cells partly correlated in time were found. The differences between these velocities generated microdeformations, which reached several tens of percent and developed within time intervals not more than 10 min. Measurements of relative magnitudes of mechanical forces influencing the cell walls suggests that microdeformations generate local stretching and compressive deformations modulating smoother tension gradients.

Journal

Russian Journal of Developmental BiologySpringer Journals

Published: Jan 22, 2016

References

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