J. Membrane Biol. 173, 165–177 (2000) The Journal of Membrane Biology © Springer-Verlag New York Inc. 2000 Topical Review Surface Antigen CD98(4F2): Not a Single Membrane Protein, But a Family of Proteins with Multiple Functions 1 2 R. Deve ´s , C.A.R. Boyd Programa de Fisiologı ´a y Biofı ´sica, Instituto de Ciencias Biome ´dicas, Facultad de Medicina, Universidad de Chile; Santiago, Chile Department of Human Anatomy and Genetics, University of Oxford, Oxford, UK Received: 10 August 1999/Revised: 28 October 1999 Introduction kDa light chain (Haynes et al., 1981); the 4F2 antibody recognized an antigenic determinant on the polypeptide backbone of the heavy chain. Later, the heavy chain was CD98(4F2) belongs to a group of approximately two described as a type II glycoprotein of 529 amino acids hundred proteins at the surface of leukocytes that are (Quackenbush et al., 1987), but the nature of the associ- thought to be important for their function in the immune ated light chain remained unknown. Recently it has been response, by specifying their migration, cell interactions shown that “the” light chain is not a single protein, but a and the signal transduction mechanisms that lead to lym- family of homologous proteins with similar
The Journal of Membrane Biology – Springer Journals
Published: Feb 1, 2000
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