Supramolecular Heteroleptic Copper(II) Carboxylates: Synthesis, Spectral Characterization, Crystal Structures, and Enzyme Inhibition Assay

Supramolecular Heteroleptic Copper(II) Carboxylates: Synthesis, Spectral Characterization,... Two new complexes of substituted phenyl acetic acids with CuSO4 · 5H2O and 2,2′-bipyridine (Bipy) with formula [CuL(Bipy)2]L · nH2O, where L = 2-ClC6H4CH2COO– (I), 2-CH3-3-NO2C6H3CH2COO– (II) and n = 3 (I); 4 (II), have been synthesized. These complexes have been characterized by elemental analysis, FT-IR and X-ray crystal diffraction (CIF file CCDC nos. 1487707 (I), 1487708 (II)). Both complexes are mononuclear and crystallize in the triclinic space group P1̅. In both complexes two molecules of Bipy bind equatorially with metal atom and one molecule of substituted phenyl acetic acid binds at axial position giving rise to a distorted five coordinated geometry around copper atom, while the second oxygen atom of carboxylate ligand appears to occupy the sixth position resulting in highly distorted six coordination environments around metal center in both complexes. However, another molecule of substituted phenyl acetic acid along with water molecules lies as co-crystal within the crystal lattice. Two bipyridine molecules in both complexes are lying in different planes and are oriented at dihedral angle of 63.89(8)° and 74.99(11)° in complexes I and II, respectively. Extensive hydrogen bonding because of water molecules present in crystal lattice plays a vital role in the formation of the 3D structure. Additionally, other weak interactions such as π–π interactions markedly influence the supramolecular structure. An investigation of DNA binding ability of both complexes using UV-visible spectroscopy and anti-diabetic capacity is also presented. Results revealed that synthesized complexes bind with SSDNA through intercalation as well as groove binding mode with K b values of 2.45 × 104 and 7.72 × 103 M–1 for complex I and II, respectively. Complex II strongly inhibits in-vitro α-glucosidase with IC50 value of 30.4 μM, while complex I moderately inhibits in-vitro α-amylase with IC50 value of 69.9 μM. Acarbose was employed as standard in both assays. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Russian Journal of Coordination Chemistry Springer Journals

Supramolecular Heteroleptic Copper(II) Carboxylates: Synthesis, Spectral Characterization, Crystal Structures, and Enzyme Inhibition Assay

Loading next page...
 
/lp/springer_journal/supramolecular-heteroleptic-copper-ii-carboxylates-synthesis-spectral-jnpUMZK4JP
Publisher
Springer Journals
Copyright
Copyright © 2018 by Pleiades Publishing, Ltd.
Subject
Chemistry; Physical Chemistry; Inorganic Chemistry
ISSN
1070-3284
eISSN
1608-3318
D.O.I.
10.1134/S1070328418030053
Publisher site
See Article on Publisher Site

Abstract

Two new complexes of substituted phenyl acetic acids with CuSO4 · 5H2O and 2,2′-bipyridine (Bipy) with formula [CuL(Bipy)2]L · nH2O, where L = 2-ClC6H4CH2COO– (I), 2-CH3-3-NO2C6H3CH2COO– (II) and n = 3 (I); 4 (II), have been synthesized. These complexes have been characterized by elemental analysis, FT-IR and X-ray crystal diffraction (CIF file CCDC nos. 1487707 (I), 1487708 (II)). Both complexes are mononuclear and crystallize in the triclinic space group P1̅. In both complexes two molecules of Bipy bind equatorially with metal atom and one molecule of substituted phenyl acetic acid binds at axial position giving rise to a distorted five coordinated geometry around copper atom, while the second oxygen atom of carboxylate ligand appears to occupy the sixth position resulting in highly distorted six coordination environments around metal center in both complexes. However, another molecule of substituted phenyl acetic acid along with water molecules lies as co-crystal within the crystal lattice. Two bipyridine molecules in both complexes are lying in different planes and are oriented at dihedral angle of 63.89(8)° and 74.99(11)° in complexes I and II, respectively. Extensive hydrogen bonding because of water molecules present in crystal lattice plays a vital role in the formation of the 3D structure. Additionally, other weak interactions such as π–π interactions markedly influence the supramolecular structure. An investigation of DNA binding ability of both complexes using UV-visible spectroscopy and anti-diabetic capacity is also presented. Results revealed that synthesized complexes bind with SSDNA through intercalation as well as groove binding mode with K b values of 2.45 × 104 and 7.72 × 103 M–1 for complex I and II, respectively. Complex II strongly inhibits in-vitro α-glucosidase with IC50 value of 30.4 μM, while complex I moderately inhibits in-vitro α-amylase with IC50 value of 69.9 μM. Acarbose was employed as standard in both assays.

Journal

Russian Journal of Coordination ChemistrySpringer Journals

Published: Mar 13, 2018

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create lists to
organize your research

Export lists, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off