Supramolecular Heteroleptic Copper(II) Carboxylates: Synthesis, Spectral Characterization, Crystal Structures, and Enzyme Inhibition Assay

Supramolecular Heteroleptic Copper(II) Carboxylates: Synthesis, Spectral Characterization,... Two new complexes of substituted phenyl acetic acids with CuSO4 · 5H2O and 2,2′-bipyridine (Bipy) with formula [CuL(Bipy)2]L · nH2O, where L = 2-ClC6H4CH2COO– (I), 2-CH3-3-NO2C6H3CH2COO– (II) and n = 3 (I); 4 (II), have been synthesized. These complexes have been characterized by elemental analysis, FT-IR and X-ray crystal diffraction (CIF file CCDC nos. 1487707 (I), 1487708 (II)). Both complexes are mononuclear and crystallize in the triclinic space group P1̅. In both complexes two molecules of Bipy bind equatorially with metal atom and one molecule of substituted phenyl acetic acid binds at axial position giving rise to a distorted five coordinated geometry around copper atom, while the second oxygen atom of carboxylate ligand appears to occupy the sixth position resulting in highly distorted six coordination environments around metal center in both complexes. However, another molecule of substituted phenyl acetic acid along with water molecules lies as co-crystal within the crystal lattice. Two bipyridine molecules in both complexes are lying in different planes and are oriented at dihedral angle of 63.89(8)° and 74.99(11)° in complexes I and II, respectively. Extensive hydrogen bonding because of water molecules present in crystal lattice plays a vital role in the formation of the 3D structure. Additionally, other weak interactions such as π–π interactions markedly influence the supramolecular structure. An investigation of DNA binding ability of both complexes using UV-visible spectroscopy and anti-diabetic capacity is also presented. Results revealed that synthesized complexes bind with SSDNA through intercalation as well as groove binding mode with K b values of 2.45 × 104 and 7.72 × 103 M–1 for complex I and II, respectively. Complex II strongly inhibits in-vitro α-glucosidase with IC50 value of 30.4 μM, while complex I moderately inhibits in-vitro α-amylase with IC50 value of 69.9 μM. Acarbose was employed as standard in both assays. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Russian Journal of Coordination Chemistry Springer Journals

Supramolecular Heteroleptic Copper(II) Carboxylates: Synthesis, Spectral Characterization, Crystal Structures, and Enzyme Inhibition Assay

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Publisher
Pleiades Publishing
Copyright
Copyright © 2018 by Pleiades Publishing, Ltd.
Subject
Chemistry; Physical Chemistry; Inorganic Chemistry
ISSN
1070-3284
eISSN
1608-3318
D.O.I.
10.1134/S1070328418030053
Publisher site
See Article on Publisher Site

Abstract

Two new complexes of substituted phenyl acetic acids with CuSO4 · 5H2O and 2,2′-bipyridine (Bipy) with formula [CuL(Bipy)2]L · nH2O, where L = 2-ClC6H4CH2COO– (I), 2-CH3-3-NO2C6H3CH2COO– (II) and n = 3 (I); 4 (II), have been synthesized. These complexes have been characterized by elemental analysis, FT-IR and X-ray crystal diffraction (CIF file CCDC nos. 1487707 (I), 1487708 (II)). Both complexes are mononuclear and crystallize in the triclinic space group P1̅. In both complexes two molecules of Bipy bind equatorially with metal atom and one molecule of substituted phenyl acetic acid binds at axial position giving rise to a distorted five coordinated geometry around copper atom, while the second oxygen atom of carboxylate ligand appears to occupy the sixth position resulting in highly distorted six coordination environments around metal center in both complexes. However, another molecule of substituted phenyl acetic acid along with water molecules lies as co-crystal within the crystal lattice. Two bipyridine molecules in both complexes are lying in different planes and are oriented at dihedral angle of 63.89(8)° and 74.99(11)° in complexes I and II, respectively. Extensive hydrogen bonding because of water molecules present in crystal lattice plays a vital role in the formation of the 3D structure. Additionally, other weak interactions such as π–π interactions markedly influence the supramolecular structure. An investigation of DNA binding ability of both complexes using UV-visible spectroscopy and anti-diabetic capacity is also presented. Results revealed that synthesized complexes bind with SSDNA through intercalation as well as groove binding mode with K b values of 2.45 × 104 and 7.72 × 103 M–1 for complex I and II, respectively. Complex II strongly inhibits in-vitro α-glucosidase with IC50 value of 30.4 μM, while complex I moderately inhibits in-vitro α-amylase with IC50 value of 69.9 μM. Acarbose was employed as standard in both assays.

Journal

Russian Journal of Coordination ChemistrySpringer Journals

Published: Mar 13, 2018

References

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