Psychopharmacology (2017) 234:2525–2543 DOI 10.1007/s00213-017-4644-3 ORIGINAL INVESTIGATION Suppressing effect of COR659 on alcohol, sucrose, and chocolate self-administration in rats: involvement of the GABA and cannabinoid CB receptors 1 1 1 1,2 Paola Maccioni & Giancarlo Colombo & Irene Lorrai & Alessandro Zaru & 3 1,2 4 4 Mauro A. M. Carai & Gian Luigi Gessa & Antonella Brizzi & Claudia Mugnaini & Federico Corelli Received: 2 December 2016 /Accepted: 9 May 2017 /Published online: 24 May 2017 Springer-Verlag Berlin Heidelberg 2017 Abstract COR659-induced reduction of alcohol self-administration, Rationale and objectives COR659 [methyl2-(4- being ineffective on reduction of chocolate self-administra- chlorophenylcarboxamido)-4-ethyl-5-methylthiophene-3- tion. Pretreatment with the cannabinoid CB receptor antago- carboxylate] is a new, positive allosteric modulator (PAM) of nist, AM4113, fully blocked COR659-induced reduction of the GABA receptor. This study evaluated whether COR659 chocolate self-administration, being ineffective on reduction shared with previously tested GABA PAMs the capacity to of alcohol self-administration. reduce alcohol self-administration in rats. Conclusions COR659 might exert its behavioral effects via a Results Treatment with non-sedative doses of COR659 (2.5, composite mechanism: (i) positive allosteric modulation of the 5, and 10 mg/kg; i.p.) suppressed lever-responding for alcohol GABA receptor, responsible for a large proportion of reduc- (15%
Psychopharmacology – Springer Journals
Published: May 24, 2017
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