Suppressing effect of COR659 on alcohol, sucrose, and chocolate self-administration in rats: involvement of the GABAB and cannabinoid CB1 receptors

Suppressing effect of COR659 on alcohol, sucrose, and chocolate self-administration in rats:... Psychopharmacology (2017) 234:2525–2543 DOI 10.1007/s00213-017-4644-3 ORIGINAL INVESTIGATION Suppressing effect of COR659 on alcohol, sucrose, and chocolate self-administration in rats: involvement of the GABA and cannabinoid CB receptors 1 1 1 1,2 Paola Maccioni & Giancarlo Colombo & Irene Lorrai & Alessandro Zaru & 3 1,2 4 4 Mauro A. M. Carai & Gian Luigi Gessa & Antonella Brizzi & Claudia Mugnaini & Federico Corelli Received: 2 December 2016 /Accepted: 9 May 2017 /Published online: 24 May 2017 Springer-Verlag Berlin Heidelberg 2017 Abstract COR659-induced reduction of alcohol self-administration, Rationale and objectives COR659 [methyl2-(4- being ineffective on reduction of chocolate self-administra- chlorophenylcarboxamido)-4-ethyl-5-methylthiophene-3- tion. Pretreatment with the cannabinoid CB receptor antago- carboxylate] is a new, positive allosteric modulator (PAM) of nist, AM4113, fully blocked COR659-induced reduction of the GABA receptor. This study evaluated whether COR659 chocolate self-administration, being ineffective on reduction shared with previously tested GABA PAMs the capacity to of alcohol self-administration. reduce alcohol self-administration in rats. Conclusions COR659 might exert its behavioral effects via a Results Treatment with non-sedative doses of COR659 (2.5, composite mechanism: (i) positive allosteric modulation of the 5, and 10 mg/kg; i.p.) suppressed lever-responding for alcohol GABA receptor, responsible for a large proportion of reduc- (15% http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Psychopharmacology Springer Journals

Suppressing effect of COR659 on alcohol, sucrose, and chocolate self-administration in rats: involvement of the GABAB and cannabinoid CB1 receptors

Loading next page...
 
/lp/springer_journal/suppressing-effect-of-cor659-on-alcohol-sucrose-and-chocolate-self-ZM7lasozVo
Publisher
Springer Berlin Heidelberg
Copyright
Copyright © 2017 by Springer-Verlag Berlin Heidelberg
Subject
Biomedicine; Neurosciences; Pharmacology/Toxicology; Psychiatry
ISSN
0033-3158
eISSN
1432-2072
D.O.I.
10.1007/s00213-017-4644-3
Publisher site
See Article on Publisher Site

Abstract

Psychopharmacology (2017) 234:2525–2543 DOI 10.1007/s00213-017-4644-3 ORIGINAL INVESTIGATION Suppressing effect of COR659 on alcohol, sucrose, and chocolate self-administration in rats: involvement of the GABA and cannabinoid CB receptors 1 1 1 1,2 Paola Maccioni & Giancarlo Colombo & Irene Lorrai & Alessandro Zaru & 3 1,2 4 4 Mauro A. M. Carai & Gian Luigi Gessa & Antonella Brizzi & Claudia Mugnaini & Federico Corelli Received: 2 December 2016 /Accepted: 9 May 2017 /Published online: 24 May 2017 Springer-Verlag Berlin Heidelberg 2017 Abstract COR659-induced reduction of alcohol self-administration, Rationale and objectives COR659 [methyl2-(4- being ineffective on reduction of chocolate self-administra- chlorophenylcarboxamido)-4-ethyl-5-methylthiophene-3- tion. Pretreatment with the cannabinoid CB receptor antago- carboxylate] is a new, positive allosteric modulator (PAM) of nist, AM4113, fully blocked COR659-induced reduction of the GABA receptor. This study evaluated whether COR659 chocolate self-administration, being ineffective on reduction shared with previously tested GABA PAMs the capacity to of alcohol self-administration. reduce alcohol self-administration in rats. Conclusions COR659 might exert its behavioral effects via a Results Treatment with non-sedative doses of COR659 (2.5, composite mechanism: (i) positive allosteric modulation of the 5, and 10 mg/kg; i.p.) suppressed lever-responding for alcohol GABA receptor, responsible for a large proportion of reduc- (15%

Journal

PsychopharmacologySpringer Journals

Published: May 24, 2017

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 12 million articles from more than
10,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Unlimited reading

Read as many articles as you need. Full articles with original layout, charts and figures. Read online, from anywhere.

Stay up to date

Keep up with your field with Personalized Recommendations and Follow Journals to get automatic updates.

Organize your research

It’s easy to organize your research with our built-in tools.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve Freelancer

DeepDyve Pro

Price
FREE
$49/month

$360/year
Save searches from
Google Scholar,
PubMed
Create lists to
organize your research
Export lists, citations
Read DeepDyve articles
Abstract access only
Unlimited access to over
18 million full-text articles
Print
20 pages/month
PDF Discount
20% off