Super-achromatic monolithic microprobe for
ultrahigh-resolution endoscopic optical coherence
tomography at 800 nm
, Robert Brown
, Wayne Mitzner
, Lonny Yarmus
& Xingde Li
Endoscopic optical coherence tomography (OCT) has emerged as a valuable tool for
advancing our understanding of the histomorphology of various internal luminal organs and
studying the pathogenesis of relevant diseases. To date, this technology affords limited
resolving power for discerning subtle pathological changes associated with early diseases. In
addition, it remains challenging to access small luminal organs or pass through narrow
luminal sections without potentially causing trauma to tissue with a traditional OCT endo-
scope of a 1-1.5 mm diameter. Here we report an ultracompact (520 µm in outer diameter and
5 mm in rigid length) and super-achromatic microprobe made with a built-in monolithic ﬁber-
optic ball lens, which achieves ultrahigh-resolution (1.7 µm axial resolution in tissue and 6 µm
transverse resolution) for endoscopic OCT imaging at 800 nm. Its performance and trans-
lational potential are demonstrated by in vivo imaging of a mouse colon, a rat esophagus, and
small airways in sheep.
Corrected: Author correction
Department of Biomedical Engineering, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA.
Department of Anesthesiology/Critical
Care Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA.
Department of Environmental Health Sciences, School of
Medicine, Johns Hopkins University, Baltimore, MD 21205, USA.
Division of Pulmonary and Critical Care Medicine, School of Medicine, Johns Hopkins
University, Baltimore, MD 21205, USA. Correspondence and requests for materials should be addressed to X.L. (email: email@example.com)