ISSN 1062-3604, Russian Journal of Developmental Biology, 2008, Vol. 39, No. 4, pp. 248–260. © Pleiades Publishing, Inc., 2008. Original Russian Text © The Editorial Board, 2008, published in Ontogenez, 2008, Vol. 39, No. 4, pp. 308–320. CHRONICLES Summary Report of the Young Scientists Conference at the Kol’tsov Institute of Developmental Biology (December 12–13, 2007) DOI: 10.1134/S1062360408040103 Regulatory Genes FGF2, Pax6, Otx2, and Six3 in Newt Retinal Regeneration P. P. Avdonin Laboratory of Regeneration Problems Retinal regeneration from pigment epithelial cells in tion factors Pax6 and Six3 as well as growth factor adult newt is under coordinated control of highly con- FGF2 was observed in multipotent neuroblasts in served regulatory genes FGF2, TGFb2, Bmp4, Pax6, regenerating retina. The expression Pax6, Six3, and Otx2, Six3, Prox1, Rx, Mitf, and Noggin encoding sig- FGF2 was also observed later during differentiation of naling and transcription factors. These genes also gov- the native retina, where the expression of the marker ern the differentiation of pigment epithelial and retinal genes βII-tubulin and Rho was initiated in parallel. cells during normal eye development in representatives During late regeneration, the Otx2 and RPE65 expres- of different taxonomic groups. We have made the ﬁrst sion was still
Russian Journal of Developmental Biology – Springer Journals
Published: Aug 9, 2008
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