Sulfuric acid-modified poly(ethylene glycol): an efficient, biodegradable, and reusable polymeric catalyst for synthesis of spiro oxindole derivatives in aqueous medium

Sulfuric acid-modified poly(ethylene glycol): an efficient, biodegradable, and reusable polymeric... A versatile, novel, and environmentally benign strategy has been successfully developed for synthesis of oxindoles, an important class of potentially bioactive compounds. Sulfonated poly(ethylene glycol) was used as inexpensive and recyclable acidic catalyst. The products were obtained in water, an excellent solvent in terms of environmental impact, in high yield, by one-pot reaction of malononitrile, 1,3-dicarbonylcoumarin or 4-hydroxycoumarin derivatives, and isatins. This new method totally avoids the use of organic acids and toxic or expensive solvents. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Research on Chemical Intermediates Springer Journals

Sulfuric acid-modified poly(ethylene glycol): an efficient, biodegradable, and reusable polymeric catalyst for synthesis of spiro oxindole derivatives in aqueous medium

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Publisher
Springer Netherlands
Copyright
Copyright © 2014 by Springer Science+Business Media Dordrecht
Subject
Chemistry; Catalysis; Physical Chemistry; Inorganic Chemistry
ISSN
0922-6168
eISSN
1568-5675
D.O.I.
10.1007/s11164-014-1627-4
Publisher site
See Article on Publisher Site

Abstract

A versatile, novel, and environmentally benign strategy has been successfully developed for synthesis of oxindoles, an important class of potentially bioactive compounds. Sulfonated poly(ethylene glycol) was used as inexpensive and recyclable acidic catalyst. The products were obtained in water, an excellent solvent in terms of environmental impact, in high yield, by one-pot reaction of malononitrile, 1,3-dicarbonylcoumarin or 4-hydroxycoumarin derivatives, and isatins. This new method totally avoids the use of organic acids and toxic or expensive solvents.

Journal

Research on Chemical IntermediatesSpringer Journals

Published: Apr 8, 2014

References

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