Sulfamic acid-catalyzed multicomponent synthesis of 7-phenyl-7,12 dihydrobenzo(h)pyrido[2,3-b]naphthydrin-6(5H)-one derivatives: a green avenue

Sulfamic acid-catalyzed multicomponent synthesis of 7-phenyl-7,12... Keywords Atom economy  Multicomponent reactions  Sulfamic acid  2-Amino pyridine  Naphthydrin derivatives Introduction Multistep synthesis of complex organic molecules does not meet the criteria of green chemistry because of several drawbacks such as the generation of waste, longer reaction time, low yield, tedious work-up procedure, etc. To overcome this issue, the scientific community has recently turned their attention towards an enviro- economic synthesis. Multicomponent reactions (MCRs) are ideal tools to overcome these drawbacks due to their remarkable advantages like high convergence, operational simplicity, facile automation, efficient work-up procedure, minimum waste generation, and enhancement atom economics rendering the protocol green [1, 2]. MCRs strategy has been realized to be a powerful means of developing drug- like heterocyclic compounds with high levels of diversity and molecular complex- ity, thereby facilitating optimization in organic synthesis [3, 4]. Therefore, the design of new MCRs with green procedures has attracted great attention, particularly in the areas of organic synthesis [5–9]. The naphthydrin skeleton, being a crucial pharmacophore present in various synthetic compounds as well as in natural products, has attracted considerable attention [10]. Neozeylanicine from the wood of Neonaucleazeylanica [11, 12], naphthyridiyl methyl ketone from Valeriana officinalis [13, 14], jasminine and Research on Chemical Intermediates Springer Journals

Sulfamic acid-catalyzed multicomponent synthesis of 7-phenyl-7,12 dihydrobenzo(h)pyrido[2,3-b]naphthydrin-6(5H)-one derivatives: a green avenue

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Springer Netherlands
Copyright © 2016 by Springer Science+Business Media Dordrecht
Chemistry; Catalysis; Physical Chemistry; Inorganic Chemistry
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