Subtype-specific prognostic impact of different immune signatures in node-negative breast cancer

Subtype-specific prognostic impact of different immune signatures in node-negative breast cancer Breast Cancer Res Treat (2017) 165:293–300 DOI 10.1007/s10549-017-4327-0 PRECLINICAL STUDY Subtype-specific prognostic impact of different immune signatures in node-negative breast cancer 1 2 3 1 1 • • • • • A.-S. Heimes K. Madjar K. Edlund M. J. Battista K. Almstedt 1 1 2 1 1 • • • • • T. Elger S. Krajnak J. Rahnenfu¨hrer W. Brenner A. Hasenburg 3 1 J. G. Hengstler M. Schmidt Received: 29 May 2017 / Accepted: 1 June 2017 / Published online: 5 June 2017 Springer Science+Business Media, LLC 2017 Abstract (HR 0.67, CI 0.46–0.97, p = 0.032). Multivariate analyses Background The role of different subtypes of immune of the immune signatures showed that both TS (p\ 0.001) cells is still a matter of debate. and BS (p\ 0.001) showed a significant prognostic Methods We compared the prognostic relevance for information in the whole cohort. After accounting for metastasis-free survival (MFS) of a B-cell signature (BS), a clinical-pathological variables, TS (p\ 0.001), BS T-cell signature (TS), and an immune checkpoint signature (p\ 0.05), and CPS (p \ 0.05) had an independent effect (CPS) in node-negative breast cancer (BC) using mRNA for MFS. In subgroup analyses, the prognostic effect of expression. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Breast Cancer Research and Treatment Springer Journals

Subtype-specific prognostic impact of different immune signatures in node-negative breast cancer

Loading next page...
 
/lp/springer_journal/subtype-specific-prognostic-impact-of-different-immune-signatures-in-Avzp1mXNv6
Publisher
Springer US
Copyright
Copyright © 2017 by Springer Science+Business Media, LLC
Subject
Medicine & Public Health; Oncology
ISSN
0167-6806
eISSN
1573-7217
D.O.I.
10.1007/s10549-017-4327-0
Publisher site
See Article on Publisher Site

Abstract

Breast Cancer Res Treat (2017) 165:293–300 DOI 10.1007/s10549-017-4327-0 PRECLINICAL STUDY Subtype-specific prognostic impact of different immune signatures in node-negative breast cancer 1 2 3 1 1 • • • • • A.-S. Heimes K. Madjar K. Edlund M. J. Battista K. Almstedt 1 1 2 1 1 • • • • • T. Elger S. Krajnak J. Rahnenfu¨hrer W. Brenner A. Hasenburg 3 1 J. G. Hengstler M. Schmidt Received: 29 May 2017 / Accepted: 1 June 2017 / Published online: 5 June 2017 Springer Science+Business Media, LLC 2017 Abstract (HR 0.67, CI 0.46–0.97, p = 0.032). Multivariate analyses Background The role of different subtypes of immune of the immune signatures showed that both TS (p\ 0.001) cells is still a matter of debate. and BS (p\ 0.001) showed a significant prognostic Methods We compared the prognostic relevance for information in the whole cohort. After accounting for metastasis-free survival (MFS) of a B-cell signature (BS), a clinical-pathological variables, TS (p\ 0.001), BS T-cell signature (TS), and an immune checkpoint signature (p\ 0.05), and CPS (p \ 0.05) had an independent effect (CPS) in node-negative breast cancer (BC) using mRNA for MFS. In subgroup analyses, the prognostic effect of expression.

Journal

Breast Cancer Research and TreatmentSpringer Journals

Published: Jun 5, 2017

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create lists to
organize your research

Export lists, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off