Breast Cancer Res Treat (2017) 165:293–300 DOI 10.1007/s10549-017-4327-0 PRECLINICAL STUDY Subtype-speciﬁc prognostic impact of different immune signatures in node-negative breast cancer 1 2 3 1 1 • • • • • A.-S. Heimes K. Madjar K. Edlund M. J. Battista K. Almstedt 1 1 2 1 1 • • • • • T. Elger S. Krajnak J. Rahnenfu¨hrer W. Brenner A. Hasenburg 3 1 J. G. Hengstler M. Schmidt Received: 29 May 2017 / Accepted: 1 June 2017 / Published online: 5 June 2017 Springer Science+Business Media, LLC 2017 Abstract (HR 0.67, CI 0.46–0.97, p = 0.032). Multivariate analyses Background The role of different subtypes of immune of the immune signatures showed that both TS (p\ 0.001) cells is still a matter of debate. and BS (p\ 0.001) showed a signiﬁcant prognostic Methods We compared the prognostic relevance for information in the whole cohort. After accounting for metastasis-free survival (MFS) of a B-cell signature (BS), a clinical-pathological variables, TS (p\ 0.001), BS T-cell signature (TS), and an immune checkpoint signature (p\ 0.05), and CPS (p \ 0.05) had an independent effect (CPS) in node-negative breast cancer (BC) using mRNA for MFS. In subgroup analyses, the prognostic effect of expression.
Breast Cancer Research and Treatment – Springer Journals
Published: Jun 5, 2017
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