Substitution of conserved cysteine residues in wheat streak mosaic virus HC-Pro abolishes virus transmission by the wheat curl mite

Substitution of conserved cysteine residues in wheat streak mosaic virus HC-Pro abolishes virus... Substitutions in the amino-proximal region of wheat streak mosaic virus (WSMV) HC-Pro were evaluated for effects on transmission by the wheat curl mite ( Aceria tosichella Keifer). Alanine substitution at cysteine residues 16, 46 and 49 abolished vector transmission. Although alanine substitution at Cys 20 had no effect, substitution with arginine reduced vector transmission efficiency. Random substitutions at other positions (Lys 7 to Asn, Asn 19 to Ile, and Arg 45 to Lys) did not affect vector transmission. These results suggest that a zinc-finger-like motif (His 13 -X2-Cys 16 -X29-Cys 46 -X2-Cys 49 ) in WSMV HC-Pro is essential for vector transmission. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Virology Springer Journals

Substitution of conserved cysteine residues in wheat streak mosaic virus HC-Pro abolishes virus transmission by the wheat curl mite

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Publisher
Springer-Verlag
Copyright
Copyright © 2007 by Springer-Verlag
Subject
Biomedicine; Virology; Medical Microbiology; Infectious Diseases
ISSN
0304-8608
eISSN
1432-8798
D.O.I.
10.1007/s00705-007-1034-x
Publisher site
See Article on Publisher Site

Abstract

Substitutions in the amino-proximal region of wheat streak mosaic virus (WSMV) HC-Pro were evaluated for effects on transmission by the wheat curl mite ( Aceria tosichella Keifer). Alanine substitution at cysteine residues 16, 46 and 49 abolished vector transmission. Although alanine substitution at Cys 20 had no effect, substitution with arginine reduced vector transmission efficiency. Random substitutions at other positions (Lys 7 to Asn, Asn 19 to Ile, and Arg 45 to Lys) did not affect vector transmission. These results suggest that a zinc-finger-like motif (His 13 -X2-Cys 16 -X29-Cys 46 -X2-Cys 49 ) in WSMV HC-Pro is essential for vector transmission.

Journal

Archives of VirologySpringer Journals

Published: Oct 1, 2007

References

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