Mammalian Genome 9, 479–481 (1998). Incorporating Mouse Genome © Springer-Verlag New York Inc. 1998 Sublocalizing the centromeric region in linkage groups from three metacentric rat chromosomes by FISH Maria Larsson,* Eva Asp,* Åsa Johansson,* Xu Chun Lu ¨ , Dan Ro ¨ hme, Go ¨ ran Levan Department of Genetics, Go ¨ teborg University, Medicinareg 9C, S-413 90 Gothenburg, Sweden Received: 7 January 1998 / Accepted: 17 February 1998 Traditionally, the mouse has been the rodent of choice for genetic (D14Mgh2), P31-H6 (D14Mit4), P443-D3 (D15Mgh1), P202-F8 experimentation, and this research has generated a large amount of (D15Mgh2), and P219-G4 (D16Mit3). mapping data in the mouse. As the focus of interest moves from For Chr 16 two additional probes were used in the FISH analy- monogenic diseases towards more complex disorders, the rat is sis. The first was a cDNA of the kallikrein 3 (Klk3) gene (Inoue et becoming more popular as a genetic model since much physiologi- al. 1989; Beaubien et al. 1991). This gene corresponds to the cal research on complex diseases has been performed in the rat. As polymorphic microsatellite marker D16Wox13 (Bihoreau et al. a consequence, many suitable rat models are available for complex 1997). The
Mammalian Genome – Springer Journals
Published: Jun 1, 1998
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