Studies on serum biochemical parameters of trop T+ or trop T− cardiac patients and evaluation of risk factors for disease outcome with a correlation to dyslipidemic rat experiment

Studies on serum biochemical parameters of trop T+ or trop T− cardiac patients and evaluation... Cardiovascular diseases (CD) are the most leading cause of death in both developed and developing nations. Diseases severity depends on multiple factors like sedentary lifestyle, smoking, diabetes, and hypertension. Blood samples from diagnosed cardiac patients from several hospitals and registered pathological centers, Midnapore District, India (Feb. 2013—Jan. 2014; >45 years, male 37, and female 23) and age-matched control (male 12 and female 9) were employed for biochemical studies on lipid profiles, SGOT, LDH, CPK/CPK-MB, and troponin T levels. Oxidative stress marker malondialdehyde (MDA), antioxidant component non-protein-soluble thiol (NPSH), and superoxide dismutase (SOD) activity were tested. High lipid or fructose-fed (90 days, isocaloric to the control) rats was investigated to evaluate some risk factors and oxidant/antioxidant status in their serum, liver, and heart tissues. Serum SGOT and LDH in female cardiac patients were found to be significantly high in both trop T− or trop T+ patients. The present multiple comparison ANOVA test suggests that most of the factors and serum markers of female cardiac patients were at higher risks (significance value, p < 0.001) than those of male patients. It is noticed that the parameters are more severely impaired in trop T+ (p < 0.001) than in trop T− (p < 0.05–0.01) patients. The malondialdehyde (MDA) and NPSH levels were found to be higher in the case of serum samples of cardiac patients. In rat experiment, mean body weight of animals did not significantly change in different nutritional groups. However, the reno-somatic index (kidney weight/100 g bw) decreased significantly both in lipid or fructose-fed group. Cholesterol and triglyceride notably increased in lipid-fed and urate decreased in either diet group. The oxidant component MDA and antioxidant enzyme catalase and SOD1 activities significantly increased/impaired in rat liver and heart of lipid-fed group. It may be hypothesized that present markers and risk factors are significant for the disease initiation and pathogenesis both in male and female. The post-menopausal age group itself may be an independent risk factor in females. The animal experiment suggests that long-term high lipid consumption may initiate dyslipidemic condition with an increase in systemic oxidative stress. Comparative Clinical Pathology Springer Journals

Studies on serum biochemical parameters of trop T+ or trop T− cardiac patients and evaluation of risk factors for disease outcome with a correlation to dyslipidemic rat experiment

Loading next page...
Springer London
Copyright © 2017 by Springer-Verlag London Ltd.
Medicine & Public Health; Pathology; Hematology; Oncology
Publisher site
See Article on Publisher Site


You’re reading a free preview. Subscribe to read the entire article.

DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 12 million articles from more than
10,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Unlimited reading

Read as many articles as you need. Full articles with original layout, charts and figures. Read online, from anywhere.

Stay up to date

Keep up with your field with Personalized Recommendations and Follow Journals to get automatic updates.

Organize your research

It’s easy to organize your research with our built-in tools.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

Monthly Plan

  • Read unlimited articles
  • Personalized recommendations
  • No expiration
  • Print 20 pages per month
  • 20% off on PDF purchases
  • Organize your research
  • Get updates on your journals and topic searches


Start Free Trial

14-day Free Trial

Best Deal — 39% off

Annual Plan

  • All the features of the Professional Plan, but for 39% off!
  • Billed annually
  • No expiration
  • For the normal price of 10 articles elsewhere, you get one full year of unlimited access to articles.



billed annually
Start Free Trial

14-day Free Trial