Novel ligand 1-((8-hydroxyquinolin-5-yl)methyl)-3-(thiazol-2-ylimino)indolin-2-one was synthesized by condensation of 5-(chloromethyl)-1,8a-dihydroquinolin-8-ol with 3-(thiazol-2-ylimino)indolin-2-one. Metal complexes of this ligand were prepared using various transition metal ion salts, viz., Mn(II), Fe(II), Co(II), Ni(II), Cu(II), and Zn(II). All synthesized compounds were characterized by various spectroscopic techniques. Thermogravimetric analysis of metal complexes was also carried out. Geometry of the metal complexes was carried out by electronic spectral analysis and magnetic measurement studies. The ligand and metal complexes were screened for their antibacterial activities against Escherichia coli, Staphylococcus aureus, Klebsiella pneumoniae, Proteus vulgaris, and Pseudomonas aeruginosa. The metal complexes are found more potent bactericides than the ligand. The interaction of ligand and its complexes with plasmid (pUC 19) DNA and calf thymus DNA was investigated by gel electrophoresis measurements. The superoxide dismutase mimetic activity of the ligand and its metal complexes has also been assessed for their ability to inhibit the reduction of nitrobluetetrazolium chloride.
Research on Chemical Intermediates – Springer Journals
Published: Jan 7, 2015
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
All the latest content is available, no embargo periods.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud