Mammalian Genome 8, 692-694 (1997). 9 Springer-Verlag New York Inc. 1997 Structure of the human UGT2B4 gene encoding a bile acid UDP-glucuronosyltransferase Gemma Monaghan, Brian Burchell, Maureen Boxer Department of Molecular and Cellular Pathology, Ninewells Hospital and Medical School, The University of Dundee, DDI 9SY, Scotland, UK Received: 25 September 1996 / Accepted: 10 April 1997 Glucuronidation, a major phase II conjugation reaction in the (Hlug25) gene, encoding a bile acid UGT (Fournel-Gigleux et al. mammalian detoxification system, is catalyzed by the UDP- 1989), has an intron/exon organization identical to the rat UGT2B glucuronosyltransferases (UGTs; Burchell and Coughtrie 1989). gene subfamily (Haque et al. 1991), thereby providing further This family of isoenzymes (50-60 kDa) is localized mainly in evidence for the existence of independent human UGT2B genes hepatic endoplasmic reticulum and nuclear envelope and has dis- rather than a single gene complex. crete but overlapping substrate specificities that permit the con- Primers were chosen from regions of the UGT2B4 (Hlug25) version of a large range of toxic endogenous and xenobiotic com- cDNA that shared least homology with other isolated human pounds to more water-soluble forms for subsequent excretion UGT2B cDNAs (Harding et al. 1988) and that would flank puta-
Mammalian Genome – Springer Journals
Published: Mar 31, 2009
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