Mammalian Genome 11, 1147–1149 (2000). DOI: 10.1007/s003350010216 Incorporating Mouse Genome © Springer-Verlag New York Inc. 2000 David J. Pennisi, Kristy M. James, Brett Hosking, George E.O. Muscat, Peter Koopman Centre for Molecular and Cellular Biology, Institute for Molecular Bioscience, The University of Queensland, Brisbane, 4072, Australia Received: 26 May 2000 / Accepted: 31 July 2000 SOX genes are found throughout the animal kingdom and encode have recently determined (Hosking et al., manuscript submitted; a highly conserved family of transcription factors involved in a GenBank accession number AF288518; Fig. 1a). However, inten- wide range of developmental processes (for review, see Wegner, sive efforts involving library screening and 58-RACE PCR have 1999). SOX proteins bind DNA in a sequence-dependent manner failed to provide further 58 human cDNA sequence. Searching of via the HMG box domain, and many have been shown to have high-throughput human genome sequence databases (http:// separable domains associated with transcriptional regulation. Sev- www.ncbi.nlm.nih.gov/BLAST/) revealed two clones from human eral SOX genes have been implicated in inherited human disor- Chromosome (Chr) 20 homologous to human SOX18. One of ders: SRY in male-to-female sex reversal and gonadal dysgenesis these (Sanger Centre clone RP11-238J15; GenBank AL356790) (Berta et al. 1990; Ja
Mammalian Genome – Springer Journals
Published: Dec 1, 2000
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