Short Communications Incorporating Mouse Genome Mammalian Genome 11, 159–163 (2000). © Springer-Verlag New York Inc. 2000 Structure and organization of the mouse Atp2a2 gene encoding the 2+ sarco(endo)plasmic reticulum Ca -ATPase 2 (SERCA2) isoforms 1, 2, 3 2 2 Mark Ver Heyen, * Thomas D. Reed, * Ruthann I. Blough, Debra L. Baker, Alla Zilberman, 2 1 1 2 1 Evgenij Loukianov, Kurt Van Baelen, Luc Raeymaekers, Muthu Periasamy, Frank Wuytack Laboratorium voor Fysiologie, Katholieke Universiteit Leuven, Campus Gasthuisberg, Herestraat 49, B-3000, Leuven, Belgium Developmental Biology Program and Division of Cardiology, University of Cincinnati, Cincinnati, Ohio, USA Division of Human Genetics, Children’s Hospital Medical Center, Cincinnati, Ohio, USA Received: 4 May 1999 / Accepted: 25 September 1999 The ATP2A2 gene encodes the sarco(endo)plasmic reticulum higher catalytic turnover rate compared with ATP2A2b (Ver- 2+ Ca -transport ATPase 2 (SERCA2), which is important for intra- boomen et al. 1994). 2+ cellular Ca homeostasis within eukaryotic cells. The ATP2A ATP2A2 gene expression is regulated by developmental and 2+ 2+ family of Ca ATPases establish and maintain intracellular Ca cell-specific regulatory cues and is also affected by hormonal and signaling stores through the ATP-dependent accumulation of cy- pathophysiological conditions of the heart (Rohrer
Mammalian Genome – Springer Journals
Published: Feb 1, 2000
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