Structure and organization of the human carboxyl ester lipase locus

Structure and organization of the human carboxyl ester lipase locus Mammalian Genome 9, 334-338 (1998). Mammalian Genome Incorporating Moose Genome © Springer-Verlag New York Inc. 1998 Katja Madeyski,* Ulf Lidberg,* Gunnar Bjursell, Jeanette Nilsson Department of Molecular Biology, Goteborg University, P.O. Box 462, S-405 30 Goteborg, Sweden Received: 17 October 1997 / Accepted: 10 December 1997 We have earlier reported the sequence of the human carboxyl ester of a recombination between two Alu elements (Lehrman et al. lipase (CEL) gene, which is constitutively expressed in pancreas 1987). Another example of a duplication mechanism is nonho- and during lactation in the mammary gland (Lidberg et al. 1992; mologous unequal crossing over, which has been shown to be Nilsson et al. 1990). It was shown that CEL is encoded by a single involved in the formation of the C4/P450c2l/X gene cluster (Gitel- gene that is 9850 bp long, consisting of 11 exons. During the man et al. 1992). screening procedure, another gene with striking similarity to the To understand the mechanisms responsible for the generation CEL gene was found, hence called the carboxyl ester lipase-like of the CEL gene and its pseudogene, the absolute organization of (CEL-like) gene. This new gene proved to span 4846 bp. Data the CEL gene and Mammalian Genome Springer Journals

Structure and organization of the human carboxyl ester lipase locus

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Copyright © 1998 by Springer-Verlag New York Inc
Life Sciences; Cell Biology; Anatomy; Zoology
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