Structure and Functions of Channel-Forming Peptides: Magainins, Cecropins, Melittin and Alamethicin

Structure and Functions of Channel-Forming Peptides: Magainins, Cecropins, Melittin and Alamethicin J. Membrane Biol. 156, 197–211 (1997) The Journal of Membrane Biology © Springer-Verlag New York Inc. 1997 Topical Review Structure and Functions of Channel-Forming Peptides: Magainins, Cecropins, Melittin and Alamethicin B. Bechinger Max-Planck-Institut fu ¨ r Biochemie, Am Klopferspitz 18a, 82152 Martinsried, Germany Received: 25 November 1996/Revised: 6 December 1996 Introduction interest for pharmacological applications are those which manifest immunological or tumoricidal activity, but un- der the same conditions, do not show hemolytic or cy- Membrane-active peptides exhibit many interesting bio- totoxic activity against healthy vertebrate cells [123]. logical and pharmacological activities. These peptides Membrane-active peptides also exhibit channel-like con- can be synthesized and purified by chemical or bio- ductivities across planar lipid bilayer systems as well as chemical means in sufficient quantities to allow for their bilayer disruption. These bilayer openings deprive the study by biophysical techniques. Whereas the character- affected organisms of their transmembrane electrochemi- istics and biological activities of some of these peptides cal gradients, result in increased water flow concomitant are highly interesting in themselves, they also provide with cell swelling, osmolysis and cell death. A detailed model systems for large membrane proteins. The study understanding of the mechanisms of channel-formation of these peptides therefore http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png The Journal of Membrane Biology Springer Journals

Structure and Functions of Channel-Forming Peptides: Magainins, Cecropins, Melittin and Alamethicin

Loading next page...
 
/lp/springer_journal/structure-and-functions-of-channel-forming-peptides-magainins-sn98iVHQB7
Publisher
Springer-Verlag
Copyright
Copyright © Inc. by 1997 Springer-Verlag New York
Subject
Life Sciences; Biochemistry, general; Human Physiology
ISSN
0022-2631
eISSN
1432-1424
D.O.I.
10.1007/s002329900201
Publisher site
See Article on Publisher Site

Abstract

J. Membrane Biol. 156, 197–211 (1997) The Journal of Membrane Biology © Springer-Verlag New York Inc. 1997 Topical Review Structure and Functions of Channel-Forming Peptides: Magainins, Cecropins, Melittin and Alamethicin B. Bechinger Max-Planck-Institut fu ¨ r Biochemie, Am Klopferspitz 18a, 82152 Martinsried, Germany Received: 25 November 1996/Revised: 6 December 1996 Introduction interest for pharmacological applications are those which manifest immunological or tumoricidal activity, but un- der the same conditions, do not show hemolytic or cy- Membrane-active peptides exhibit many interesting bio- totoxic activity against healthy vertebrate cells [123]. logical and pharmacological activities. These peptides Membrane-active peptides also exhibit channel-like con- can be synthesized and purified by chemical or bio- ductivities across planar lipid bilayer systems as well as chemical means in sufficient quantities to allow for their bilayer disruption. These bilayer openings deprive the study by biophysical techniques. Whereas the character- affected organisms of their transmembrane electrochemi- istics and biological activities of some of these peptides cal gradients, result in increased water flow concomitant are highly interesting in themselves, they also provide with cell swelling, osmolysis and cell death. A detailed model systems for large membrane proteins. The study understanding of the mechanisms of channel-formation of these peptides therefore

Journal

The Journal of Membrane BiologySpringer Journals

Published: Apr 1, 1997

There are no references for this article.

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create lists to
organize your research

Export lists, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off