Short Communications e//o///e Mammalian Genome 8, 139-140 (1997). 9 Springer-Verlag New York Inc. 1997 Structure and chromosomal localization of the mouse mitochondrial transcription factor A gene (Tfam)* Nils-G6ran Larsson, 1 Gregory S. Barsh, z David A. Clayton ~ 1Department of Developmental Biology, Stanford University School of Medicine, Stanford, California 94305-5427, USA 2Departments of Pediatrics and Genetics, Howard Hughes Medical Insutute, Stanford University School of Medicine, Stanford, California 94305-5428, USA Received: 22 August 1996 / Accepted: 28 September 1996 Mitochondrial transcription factor A (mtTFA) is encoded by a nuclear gene and imported to mitoehondria, where it functions as A a key regulator of mammalian mitochondrial DNA transcription (Clayton 1991). We recently reported eDNA cloning and expres- Exon: iT h w r sion studies of the mouse mtTFA gene (Larsson et al. 1996), which has been named Tram in accord with accepted nomenclature and to correspond with the human homolog TFAM, previously described as TCF6 (Tiranti et al. 1995). We demonstrated that Tfam is widely expressed and that its transcripts are alternately spliced in testis; one of the three testis-specific Tram transcript isoforms encodes a protein that lacks most of the mitochondrial targeting signal and is Splxce donor sites A g
Mammalian Genome – Springer Journals
Published: Mar 24, 2009
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