Curr Trop Med Rep (2017) 4:103–110 DOI 10.1007/s40475-017-0117-3 MELIOIDOSIS AND TROPICAL BACTERIOLOGY (A TORRES, SECTION EDITOR) Structural Vaccinology for Melioidosis Vaccine Design and Immunodiagnostics 1 2,3 1 2 Alessandro Gori & Martino Bolognesi & Giorgio Colombo & Louise J. Gourlay Published online: 19 July 2017 Springer International Publishing AG 2017 Abstract a single scaffold to generate components, stimulating both Purpose of Review Spurred by the successful application of arms of the immune system. structural vaccinology to other challenging bacterial and viral . . . pathogens, we review the possibility of exploiting 3D struc- Keywords Melioidosis Vaccines Epitope design . . ture computational-based recombinant antigen engineering Structural vaccinology B. pseudomallei Antigens strategies for the development of a protective melioidosis vaccine. Recent Findings Structure-based epitope design approaches Introduction in the melioidosis field are preliminary and applied essentially by one research network. By combining Burkholderia Melioidosis is a potentially fatal disease caused by the soil- pseudomallei antigen 3D structures and in silico epitope dis- borne, intracellular Gram-negative bacillus Burkholderia covery methods, a panel of synthetic epitope peptides were pseudomallei, endemic in the tropical and subtropical re- designed and tested for their B and T cell stimulatory activi- gions of the world .
Current Tropical Medicine Reports – Springer Journals
Published: Jul 19, 2017
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