Structural requirements of glycosaminoglycans for their interaction with HIV-1 envelope glycoprotein gp120

Structural requirements of glycosaminoglycans for their interaction with HIV-1 envelope... Heparan sulfate proteoglycans are known to assist HIV-1 entry into host cells, mediated by the viral envelope glycoprotein gp120. We aimed to determine the general structural features of glycosaminoglycans that enable their binding to gp120, by surface plasmon resonance. Binding was found to be dependent on sequence type, size and sulfation patterns. HIV-1 gp120 prefers heparin and heparan sulfate (with at least 16 monomers in length) over chondroitin and dermatan. Sulfate groups were essential to promote this interaction. These results advance the understanding of the molecular-level requirements for virus attachment and cell entry. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Virology Springer Journals

Structural requirements of glycosaminoglycans for their interaction with HIV-1 envelope glycoprotein gp120

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Publisher
Springer Vienna
Copyright
Copyright © 2014 by Springer-Verlag Wien
Subject
Biomedicine; Virology; Medical Microbiology; Infectious Diseases
ISSN
0304-8608
eISSN
1432-8798
D.O.I.
10.1007/s00705-013-1831-3
Publisher site
See Article on Publisher Site

Abstract

Heparan sulfate proteoglycans are known to assist HIV-1 entry into host cells, mediated by the viral envelope glycoprotein gp120. We aimed to determine the general structural features of glycosaminoglycans that enable their binding to gp120, by surface plasmon resonance. Binding was found to be dependent on sequence type, size and sulfation patterns. HIV-1 gp120 prefers heparin and heparan sulfate (with at least 16 monomers in length) over chondroitin and dermatan. Sulfate groups were essential to promote this interaction. These results advance the understanding of the molecular-level requirements for virus attachment and cell entry.

Journal

Archives of VirologySpringer Journals

Published: Mar 1, 2014

References

  • The molecular basis of HIV entry
    Klasse, PJ
  • Functions of cell surface heparan sulfate proteoglycans
    Bernfield, M; Gotte, M; Park, PW; Reizes, O; Fitzgerald, ML; Lincecum, J; Zako, M

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