Structural Insights into the CFTR-NHERF Interaction

Structural Insights into the CFTR-NHERF Interaction J. Membrane Biol. 192, 79–88 (2003) DOI: 10.1007/s00232-002-1065-x Topical Review J.A.A. Ladias Molecular Medicine Laboratory and Macromolecular Crystallography Unit, Division of Experimental Medicine, Harvard Institutes of Medicine, Harvard, Medical School, 4Blackfan Circle, Boston Massachusetts 02115, USA Received: 26 July 2002/Revised: 28 October 2002 Introduction mains may be expressed as separate polypeptides or half-transporters, such as the putative lipid A trans- The cystic fibrosis transmembrane conductance reg- porter MsbA from Escherichia coli [8], or fused to- ulator (CFTR) is a low-conductance chloride channel gether in a single polypeptide, as in the CFTR protein. located at the apical membrane of epithelial cells The energy of ATP binding and hydrolysis is used to where it mediates cAMP-dependent chloride secre- select and transport the substrates through the lipid tion (reviewed in [2, 23, 71]). Abnormal CFTR bilayer by unknown mechanisms. The current draft of function is associated with the pathogenesis of human the human genome sequence contains 48 ABC genes, diseases, including cystic fibrosis, secretory diarrhea, 16 of which encode transporters with known function, and pancreatitis [2, 20]. Cystic fibrosis is caused by including the multidrug resistance protein, the trans- mutations in the CFTR gene that decrease the cell porter for antigen presentation, http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png The Journal of Membrane Biology Springer Journals

Structural Insights into the CFTR-NHERF Interaction

Loading next page...
 
/lp/springer_journal/structural-insights-into-the-cftr-nherf-interaction-Fm78ttkYuD
Publisher
Springer-Verlag
Copyright
Copyright © 2003 by Springer-Verlag New York Inc.
Subject
Life Sciences; Biochemistry, general; Human Physiology
ISSN
0022-2631
eISSN
1432-1424
D.O.I.
10.1007/s00232-002-1065-x
Publisher site
See Article on Publisher Site

There are no references for this article.

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 12 million articles from more than
10,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Unlimited reading

Read as many articles as you need. Full articles with original layout, charts and figures. Read online, from anywhere.

Stay up to date

Keep up with your field with Personalized Recommendations and Follow Journals to get automatic updates.

Organize your research

It’s easy to organize your research with our built-in tools.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

Monthly Plan

  • Read unlimited articles
  • Personalized recommendations
  • No expiration
  • Print 20 pages per month
  • 20% off on PDF purchases
  • Organize your research
  • Get updates on your journals and topic searches

$49/month

Start Free Trial

14-day Free Trial

Best Deal — 39% off

Annual Plan

  • All the features of the Professional Plan, but for 39% off!
  • Billed annually
  • No expiration
  • For the normal price of 10 articles elsewhere, you get one full year of unlimited access to articles.

$588

$360/year

billed annually
Start Free Trial

14-day Free Trial