Structural Characterization and Absolute Quantification of Microcystin Peptides Using Collision-Induced and Ultraviolet Photo-Dissociation Tandem Mass Spectrometry

Structural Characterization and Absolute Quantification of Microcystin Peptides Using... B American Society for Mass Spectrometry, 2018 J. Am. Soc. Mass Spectrom. (2018) DOI: 10.1007/s13361-018-1981-3 FOCUS: APPLICATION OF PHOTONS AND RADICALS FOR MS: RESEARCH ARTICLE Structural Characterization and Absolute Quantification of Microcystin Peptides Using Collision-Induced and Ultraviolet Photo-Dissociation Tandem Mass Spectrometry 1,2 3 1 3 Troy J. Attard, Melissa D. Carter, Mengxuan Fang, Rudolph C. Johnson, 1,2,4 Gavin E. Reid School of Chemistry, The University of Melbourne, Melbourne, VIC, Australia Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, VIC, Australia Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA, USA Department of Biochemistry and Molecular Biology, The University of Melbourne, Melbourne, VIC, Australia Abstract. Microcystin (MC) peptides produced by cyanobacteria pose a hepatotoxic threat to human health upon ingestion from contaminated drinking water. While rapid MC identification and quantifica- tion in contaminated body fluids or tissue samples is important for patient treatment and outcomes, con- ventional immunoassay-based measurement strat- egies typically lack the specificity required for unam- biguous determination of specific MC variants, whose toxicity can significantly vary depending on their structures. Furthermore, the unambiguous identification and accurate quantitation of MC variants using tandem mass spectrometry (MS/MS)-based methods http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of The American Society for Mass Spectrometry Springer Journals

Structural Characterization and Absolute Quantification of Microcystin Peptides Using Collision-Induced and Ultraviolet Photo-Dissociation Tandem Mass Spectrometry

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Publisher
Springer US
Copyright
Copyright © 2018 by American Society for Mass Spectrometry
Subject
Chemistry; Analytical Chemistry; Biotechnology; Organic Chemistry; Proteomics; Bioinformatics
ISSN
1044-0305
eISSN
1879-1123
D.O.I.
10.1007/s13361-018-1981-3
Publisher site
See Article on Publisher Site

Abstract

B American Society for Mass Spectrometry, 2018 J. Am. Soc. Mass Spectrom. (2018) DOI: 10.1007/s13361-018-1981-3 FOCUS: APPLICATION OF PHOTONS AND RADICALS FOR MS: RESEARCH ARTICLE Structural Characterization and Absolute Quantification of Microcystin Peptides Using Collision-Induced and Ultraviolet Photo-Dissociation Tandem Mass Spectrometry 1,2 3 1 3 Troy J. Attard, Melissa D. Carter, Mengxuan Fang, Rudolph C. Johnson, 1,2,4 Gavin E. Reid School of Chemistry, The University of Melbourne, Melbourne, VIC, Australia Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, VIC, Australia Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA, USA Department of Biochemistry and Molecular Biology, The University of Melbourne, Melbourne, VIC, Australia Abstract. Microcystin (MC) peptides produced by cyanobacteria pose a hepatotoxic threat to human health upon ingestion from contaminated drinking water. While rapid MC identification and quantifica- tion in contaminated body fluids or tissue samples is important for patient treatment and outcomes, con- ventional immunoassay-based measurement strat- egies typically lack the specificity required for unam- biguous determination of specific MC variants, whose toxicity can significantly vary depending on their structures. Furthermore, the unambiguous identification and accurate quantitation of MC variants using tandem mass spectrometry (MS/MS)-based methods

Journal

Journal of The American Society for Mass SpectrometrySpringer Journals

Published: May 29, 2018

References

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