Homolog pairing, chromosome morphology, and chromosome disjunction in the first meiotic division were studied in the oocytes of c(3)G/c(3)Gfemale Drosophila melanogasterat developmental stages 3–4 and 14. It was found that homologs were completely or partly paired in some cells (about 20% in either case). The lengths of chromosomes in +/+, +/c(3)G, and c(3)G/c(3)Gcells were at a ratio of 1.0 : 1.6 : 2.2. The chromocenters of homozygous cells had an abnormal structure. There was no meiotic block in metaphase 1, and chromosomes only segregated equally in about 80% of anaphases of the first meiotic division. The data obtained correspond to the abnormal variants of the formation of the chromocenter in c(3)G/c(3)Gfemales that could be predicted based on the two-ring structure of the chromocenter. The mechanism of the effect of the homo- and heterozygosity for the hypomorphic mutation c(3)Gon the formation of the synaptonemal complex (SC) and crossing over frequency was suggested. In nod/nodhomozygous females, asynapsis of pericentromeric regions of homologs was observed in the chromocenter. It was assumed that NOD kinezin is necessary at the last stages of pairing of the pericentromeric regions of homologs and formation of the coordinating bonds between them.
Russian Journal of Genetics – Springer Journals
Published: Oct 16, 2004
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