Stress proteins in the pathogenesis of spondyloarthritis

Stress proteins in the pathogenesis of spondyloarthritis Spondyloarthritis is an autoinflammatory rheumatic disease in which arthritis and osteoproliferation lead the patients who suffer from it to chronic disability. This disease is associated with the expression of class I MHC molecule HLA-B27, which tends to be misfolded in the endoplasmic reticulum and, therefore, expressed in aberrant forms. This phenomena lead to endoplasmic reticulum stress, which in time, evokes a whole response to cellular injury. Under these conditions, the mol- ecules involved in restoring cell homeostasis play a key role. Such is the case of the “heat-shock proteins”, which usually regulate protein folding, but also have important immunomodulatory functions, as well as some roles in tissue modeling. In this review, we attempt to summarize the involvement of cell stress and heat-shock proteins in the homeostatic disturbances and pathological conditions associated with this disease. Keywords Spondyloarthritis · Heat-shock proteins · Cell stress · HLA-B27 · HSP60 General remarks as peripheral oligoarthritis, uveitis, psoriasis and intestinal inflammation can occur [2 ]. Spondyloarthritis (SpA) is the term used to describe a group One of the big problems when studying the SpA is the of clinical entities that share some clinical and pathological unification of concepts about the clinical criteria and the features. Originally, the term http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Rheumatology International Springer Journals

Stress proteins in the pathogenesis of spondyloarthritis

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Publisher
Springer Journals
Copyright
Copyright © 2018 by Springer-Verlag GmbH Germany, part of Springer Nature
Subject
Medicine & Public Health; Rheumatology
ISSN
0172-8172
eISSN
1437-160X
D.O.I.
10.1007/s00296-018-4070-9
Publisher site
See Article on Publisher Site

Abstract

Spondyloarthritis is an autoinflammatory rheumatic disease in which arthritis and osteoproliferation lead the patients who suffer from it to chronic disability. This disease is associated with the expression of class I MHC molecule HLA-B27, which tends to be misfolded in the endoplasmic reticulum and, therefore, expressed in aberrant forms. This phenomena lead to endoplasmic reticulum stress, which in time, evokes a whole response to cellular injury. Under these conditions, the mol- ecules involved in restoring cell homeostasis play a key role. Such is the case of the “heat-shock proteins”, which usually regulate protein folding, but also have important immunomodulatory functions, as well as some roles in tissue modeling. In this review, we attempt to summarize the involvement of cell stress and heat-shock proteins in the homeostatic disturbances and pathological conditions associated with this disease. Keywords Spondyloarthritis · Heat-shock proteins · Cell stress · HLA-B27 · HSP60 General remarks as peripheral oligoarthritis, uveitis, psoriasis and intestinal inflammation can occur [2 ]. Spondyloarthritis (SpA) is the term used to describe a group One of the big problems when studying the SpA is the of clinical entities that share some clinical and pathological unification of concepts about the clinical criteria and the features. Originally, the term

Journal

Rheumatology InternationalSpringer Journals

Published: May 31, 2018

References

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