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Wanfang Su, B. Shmukler, M. Chernova, A. Stuart-Tilley, L. Franceschi, C. Brugnara, C. Brugnara, Seth Alper (1999)
Mouse K-Cl cotransporter KCC1: cloning, mapping, pathological expression, and functional regulation.The American journal of physiology, 277 5
Christine Pellegrino, A. Rybicki, Sylvia Musto, Ronald Nagel, Robert Schwartz (1998)
Molecular identification and expression of erythroid K:Cl cotransporter in human and mouse erythroleukemic cells.Blood cells, molecules & diseases, 24 1
P. Lauf, J. Bauer, N. Adragna, H. Fujise, A. Zade-Oppen, Kyoo Ryu, E. Delpire (1992)
Erythrocyte K-Cl cotransport: properties and regulation.The American journal of physiology, 263 5 Pt 1
H. Sheerin, L. Snyder, G. Fairbanks (1989)
Cation transport in oxidant-stressed human erythrocytes: heightened N-ethylmaleimide activation of passive K+ influx after mild peroxidation.Biochimica et biophysica acta, 983 1
O. Lowry, N. Rosebrough, A. Farr, R. Randall (1951)
Protein measurement with the Folin phenol reagent.The Journal of biological chemistry, 193 1
J. Willis, G. Anderson (1998)
Activation of K-Cl Cotransport by Mild Warming in Guinea Pig Red CellsThe Journal of Membrane Biology, 163
C. Brugnara, D. Tosteson (1987)
Cell volume, K transport, and cell density in human erythrocytes.The American journal of physiology, 252 3 Pt 1
Isabel Bize, Isabel Bize, Patricia Muñoz, Mitzy Canessa, Philip Dunham (1998)
Stimulation of membrane serine-threonine phosphatase in erythrocytes by hydrogen peroxide and staurosporine.The American journal of physiology, 274 2
Philip Dunham (1995)
Effects of urea on K-Cl cotransport in sheep red blood cells: evidence for two signals of swelling.The American journal of physiology, 268 4 Pt 1
P. Lauf, B. Theg (1980)
A chloride dependent K+ flux induced by N-ethylmaleimide in genetically low K+ sheep and goat erythrocytes.Biochemical and biophysical research communications, 92 4
G. Stewart (1991)
'Physiological membrane stabilisation': a possible explanation for the K(+)-H+ and K(+)-Mg2+ relations in disease.Mineral and electrolyte metabolism, 17 5
P. Flatman, N. Adragna, P. Lauf (1996)
Role of protein kinases in regulating sheep erythrocyte K-Cl cotransport.The American journal of physiology, 271 1 Pt 1
Michael Jennings, K. Richard, Schulz (1991)
Okadaic acid inhibition of KCl cotransport. Evidence that protein dephosphorylation is necessary for activation of transport by either cell swelling or N-ethylmaleimideThe Journal of General Physiology, 97
P. Lauf, A. Erdmann, N. Adragna (1994)
K-Cl cotransport, pH, and role of Mg in volume-clamped low-K sheep erythrocytes: three equilibrium states.The American journal of physiology, 266 1 Pt 1
D. Kaji, Y. Tsukitani (1991)
Role of protein phosphatase in activation of KCl cotransport in human erythrocytes.The American journal of physiology, 260 1 Pt 1
Isabel Bize, Philip Dunham (1994)
Staurosporine, a protein kinase inhibitor, activates K-Cl cotransport in LK sheep erythrocytes.The American journal of physiology, 266 3 Pt 1
L. Starke, Michael Jennings (1993)
K-Cl cotransport in rabbit red cells: further evidence for regulation by protein phosphatase type 1.The American journal of physiology, 264 1 Pt 1
O. Ortiz-Carranza, N. Adragna, P. Lauf (1996)
Modulation of K-Cl cotransport in volume-clamped low-K sheep erythrocytes by pH, magnesium, and ATP.The American journal of physiology, 271 4 Pt 1
L. Franceschi, Laura Fumagalli, O. Olivieri, Roberto Corrocher, Clifford Lowell, Giorgio Berton (1997)
Deficiency of Src family kinases Fgr and Hck results in activation of erythrocyte K/Cl cotransport.The Journal of clinical investigation, 99 2
C. Brugnara, H. Bunn, D. Tosteson (1986)
Regulation of erythrocyte cation and water content in sickle cell anemia.Science, 232 4748
Y. Zipser, Adi Piade, N. Kosower (1997)
Erythrocyte thiol status regulates band 3 phosphotyrosine level via oxidation/reduction of band 3‐associated phosphotyrosine phosphataseFEBS Letters, 406
Mitzy Canessa, ME Fabry, RL Nagel (1987)
Deoxygenation inhibits the volume-stimulated, Cl(-)-dependent K+ efflux in SS and young AA cells: a cytosolic Mg2+ modulation.Blood, 70 6
Philip Dunham, Jadwiga Kl1mczak, P. Logue, Dunham (1993)
Swelling activation of K-Cl cotransport in LK sheep erythrocytes: a three-state processThe Journal of General Physiology, 101
T. Krarup, P. Dunham (1996)
Reconstitution of calyculin-inhibited K-Cl cotransport in dog erythrocyte ghosts by exogenous PP-1.The American journal of physiology, 270 3 Pt 1
I. Bize, B. Güvenc, A. Robb, G. Buchbinder, C. Brugnara (1999)
Serine/threonine protein phosphatases and regulation of K-Cl cotransport in human erythrocytes.American journal of physiology. Cell physiology, 277 5
A. Cossins, Y. Weaver, G. Lykkeboe, O. Nielsen (1994)
Role of protein phosphorylation in control of K flux pathways of trout red blood cells.The American journal of physiology, 267 6 Pt 1
H. Godart, J. Ellory (1996)
KCl cotransport activation in human erythrocytes by high hydrostatic pressure.The Journal of Physiology, 491
John Parker (1993)
Urea alters set point volume for K-Cl cotransport, Na-H exchange, and Ca-Na exchange in dog red blood cells.The American journal of physiology, 265 2 Pt 1
M. Jennings (1999)
Volume-Sensitive K+/Cl− Cotransport in Rabbit ErythrocytesThe Journal of General Physiology, 114
Clinton Joiner (1993)
Cation transport and volume regulation in sickle red blood cells.The American journal of physiology, 264 2 Pt 1
E. Orringer, J. Brockenbrough, J. Whitney, P. Glosson, J. Parker (1991)
Okadaic acid inhibits activation of K-Cl cotransport in red blood cells containing hemoglobins S and C.The American journal of physiology, 261 4 Pt 1
Carlo Brugnara, D. Tosteson (1987)
Inhibition of K transport by divalent cations in sickle erythrocytes.Blood, 70 6
M. Fabry, Jose Romero, Iris Buchanan, S. Suzuka, George Stamatoyannopoulos, Ronald Nagel, Mitzy Canessa (1991)
Rapid increase in red blood cell density driven by K:Cl cotransport in a subset of sickle cell anemia reticulocytes and discocytes.Blood, 78 1
E. Villa-Moruzzi, M. Tognarini, G. Cecchini, P. Marchisio (1998)
Protein phosphatase 1 delta is associated with focal adhesions.Cell adhesion and communication, 5 4
Michael Jennings, Nayef Al-Rohil (1990)
Kinetics of activation and inactivation of swelling-stimulated K+/Cl- transport. The volume-sensitive parameter is the rate constant for inactivationThe Journal of General Physiology, 95
J. Ellory, P. Flatman, G. Stewart (1983)
Inhibition of human red cell sodium and potassium transport by divalent cations.The Journal of Physiology, 340
E. Hoffmann, Philip Dunham (1995)
Membrane mechanisms and intracellular signalling in cell volume regulation.International review of cytology, 161
C. Armsby, C. Brugnara, Seth Alper (1995)
Cation transport in mouse erythrocytes: role of K(+)-Cl- cotransport in regulatory volume decrease.The American journal of physiology, 268 4 Pt 1
S. Kelley, Philip Dunham (1996)
Mechanism of swelling activation of K-Cl cotransport in inside-out vesicles of LK sheep erythrocyte membranes.The American journal of physiology, 270 4 Pt 1
C. Kamibayashi, R. Estes, Clive Slaughter, M. Mumby, M. Mumby (1991)
Subunit interactions control protein phosphatase 2A. Effects of limited proteolysis, N-ethylmaleimide, and heparin on the interaction of the B subunit.The Journal of biological chemistry, 266 20
Isabel Bize, Philip Dunham (1995)
H2O2 activates red blood cell K-Cl cotransport via stimulation of a phosphatase.The American journal of physiology, 269 4 Pt 1
H. Ishihara, B. Martin, D. Brautigan, H. Karaki, H. Ozaki, Y. Kato, N. Fusetani, S. Watabe, Koji Hashimoto, D. Uemura, D. Hartshorne (1989)
Calyculin A and okadaic acid: inhibitors of protein phosphatase activity.Biochemical and biophysical research communications, 159 3
An increase in the activity of membrane-associated protein phosphatase type 1 (mb-PP1) is associated with stimulation of erythrocyte K-Cl cotransport (KCC). We have recently proposed that membrane-associated protein phosphatase type 2A (mb-PP2A) is also involved in KCC regulation by cell swelling (Bize et al., 1999. Am. J. Physiol. 277:C899–C912). We used two protein phosphatase inhibitors, okadaic acid (OA) and calyculin A (CalA), and two KCC activating treatments, n-ethylmaleimide (NEM) and Mg i ++-depletion, and determined KCC transport activity and mb-PP1 and mb-PP2A activities. OA, an inhibitor of erythrocyte mb-PP2A, partially prevents stimulation of KCC activity by NEM but not by Mg i ++-depletion. CalA, an inhibitor of both mb-PP1 and mb-PP2A prevents stimulation of KCC activity by both treatments. NEM and Mg i ++-depletion inhibit mb-PP1 activity, suggesting that activation of KCC can take place in the absence of mb-PP1 activation. Mb-PP2A activity is stimulated in NEM-treated cells but not in Mg i ++-depleted cells. In NEM-treated cells, Mg i ++-depletion inhibits both KCC and mb-PP2A. In Mg i ++-depleted cells, NEM does not stimulate KCC or mb-PP2A. The strong correlation between KCC stimulation and mb-PP2A stimulation provides further support to the idea that mb-PP2A plays an important role in KCC regulation. Our results are consistent with the hypothesis that KCC regulation involves at least two distinguishable phosphorylation sites.
The Journal of Membrane Biology – Springer Journals
Published: Sep 15, 2000
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