Stimulated Motion Suppression (STMS): a New Approach to Break the Resolution Barrier for Ion Trap Mass Spectrometry

Stimulated Motion Suppression (STMS): a New Approach to Break the Resolution Barrier for Ion Trap... B American Society for Mass Spectrometry, 2018 J. Am. Soc. Mass Spectrom. (2018) 29:1738Y1744 DOI: 10.1007/s13361-018-1995-x RESEARCH ARTICLE Stimulated Motion Suppression (STMS): a New Approach to Break the Resolution Barrier for Ion Trap Mass Spectrometry 1 1 1,2 1 1 1,2 Xiaoyu Zhou, Xinwei Liu, Spencer Chiang, Wenbo Cao, Ming Li, Zheng Ouyang State Key Laboratory of Precision Measurement Technology and Instruments, Department of Precision Instrument, Tsinghua University, Beijing, 100084, China Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 47907, USA Abstract. Ion trap is an excellent platform to per- form tandem mass spectrometry (MS/MS), but has an intrinsic drawback in resolving power. STMS Using ion resonant ejection as an example, the resolution degradation can be largely attributed to the broadening of the resonant frequency band (RFB) between ion motion and driving alternative- current (AC). To solve this problem, stimulated motion suppression (STMS) was developed. The key idea of STMS is the use of two suppres- sion alternative-current (SAC) signals, which both have reversed initial phases to the main AC. The SACs can block the unexpected sideband ion resonances (or ejections), therefore playing a key role in sharpening the RFB. The proof-of-concept has been demonstrated through ion http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of The American Society for Mass Spectrometry Springer Journals

Stimulated Motion Suppression (STMS): a New Approach to Break the Resolution Barrier for Ion Trap Mass Spectrometry

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Publisher
Springer US
Copyright
Copyright © 2018 by American Society for Mass Spectrometry
Subject
Chemistry; Analytical Chemistry; Biotechnology; Organic Chemistry; Proteomics; Bioinformatics
ISSN
1044-0305
eISSN
1879-1123
D.O.I.
10.1007/s13361-018-1995-x
Publisher site
See Article on Publisher Site

Abstract

B American Society for Mass Spectrometry, 2018 J. Am. Soc. Mass Spectrom. (2018) 29:1738Y1744 DOI: 10.1007/s13361-018-1995-x RESEARCH ARTICLE Stimulated Motion Suppression (STMS): a New Approach to Break the Resolution Barrier for Ion Trap Mass Spectrometry 1 1 1,2 1 1 1,2 Xiaoyu Zhou, Xinwei Liu, Spencer Chiang, Wenbo Cao, Ming Li, Zheng Ouyang State Key Laboratory of Precision Measurement Technology and Instruments, Department of Precision Instrument, Tsinghua University, Beijing, 100084, China Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 47907, USA Abstract. Ion trap is an excellent platform to per- form tandem mass spectrometry (MS/MS), but has an intrinsic drawback in resolving power. STMS Using ion resonant ejection as an example, the resolution degradation can be largely attributed to the broadening of the resonant frequency band (RFB) between ion motion and driving alternative- current (AC). To solve this problem, stimulated motion suppression (STMS) was developed. The key idea of STMS is the use of two suppres- sion alternative-current (SAC) signals, which both have reversed initial phases to the main AC. The SACs can block the unexpected sideband ion resonances (or ejections), therefore playing a key role in sharpening the RFB. The proof-of-concept has been demonstrated through ion

Journal

Journal of The American Society for Mass SpectrometrySpringer Journals

Published: May 29, 2018

References

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