Russian Journal of Developmental Biology, Vol. 34, No. 3, 2003, pp. 128–130. Translated from Ontogenez, Vol. 34, No. 3, 2003, pp. 164–166. Original Russian Text Copyright © 2003 by Korochkin. STATE OF THE PROBLEM used. They are not rejected and, in addition, their malig- nant transformation is excluded. Stem cells are the cells that preserve the potential The stromal cell therapy is widely used in orthope- for development in different directions. The stem cell dics. This is related to the existence of special proteins, can give rise to skin, nerve, or blood cells. bone morphogenetic proteins (BMP), that induce dif- Two kinds of stem cells are distinguished: embry- ferentiation of the stromal cells into osteoblasts. The onic stem cells (ESC) and regional stem cells (SC). clinical tests gave very promising results. For example, The former are present at the earliest stages of develop- in the USA a special collagen plate with BMP was ment, before the beginning of organogenesis. The latter transplanted into a 91-year old patient with a fracture are found later, when organs and tissues are formed. It nonhealing for 13 years. The stromal cells coming to was believed that the adult organism is devoid of SCs.
Russian Journal of Developmental Biology – Springer Journals
Published: Oct 7, 2004
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