Stem Cell Reviews and Reports (2018) 14:642–667 https://doi.org/10.1007/s12015-018-9825-x 1 1 1 2 1 Dorothee Hielscher & Constanze Kaebisch & Benedikt Julius Valentin Braun & Kevin Gray & Edda Tobiasch Published online: 2 June 2018 Springer Science+Business Media, LLC, part of Springer Nature 2018 . . . . . . . Keywords Angiogenesis Vascular cells Graft material Stem cells Sprouting Vascular grafts Tissue engineering Vasculature Introduction induced pluripotent stem cells (iPSCs) [5, 6]. Besides these two pluripotent stem cell types, research efforts also focus on Coronary artery disease represents the most common type of adult, multipotent mesenchymal stem cells (MSCs) since they heart disease and accounts for about 7.4 million deaths world- show, in contrast to ESC and iPSCs, no detectable teratoma wide in 2012 . Prognoses indicate that annual mortality formation . This relative safety has brought adult stem cell from this condition will increase because the aging population approaches farther towards therapeutic application than any also raises the prevalence of patients with multimorbidity and other stem cell type . Theoretically, stem cell-based ap- chronic conditions. This phenomenon already poses a great proaches have the capacity to give rise to new blood vessels. challenge to regenerative medicine approaches because
Stem Cell Reviews and Reports – Springer Journals
Published: Jun 2, 2018
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