Psychopharmacology (2017) 234:2697–2705 DOI 10.1007/s00213-017-4656-z ORIGINAL INVESTIGATION Steep effort discounting of a preferred reward over a freely-available option in prolonged methamphetamine withdrawal in male rats 1 1 1 1 Andrew B. Thompson & Julian Gerson & Alexandra Stolyarova & Amador Bugarin & 1 1,2,3,4 1,3,4 Evan E. Hart & J. David Jentsch & Alicia Izquierdo Received: 12 December 2016 /Accepted: 23 May 2017 /Published online: 6 June 2017 Springer-Verlag Berlin Heidelberg 2017 Abstract reward to the chow sooner than saline-pretreated rats Rationale Drug addiction can be described as aberrant alloca- (p < 0.05). This effect was not consistent with general reward tion of effort toward acquiring drug, despite associated costs. devaluation or loss of motivation. It is unclear if this behavioral pattern results from an overvalu- Conclusions These findings demonstrate that mAMPH expo- ation of reward or to an altered sensitivity to costs. sure and withdrawal lead to steeper discounting of reward Objective Present experiments assessed reward sensitivity value by effort, an effect that is consistent with the effect of and effortful choice in rats following 1 week of withdrawal mAMPH on discounting by delay, and which may reflect an from methamphetamine (mAMPH). underlying shared mechanism. Methods Rats were
Psychopharmacology – Springer Journals
Published: Jun 6, 2017
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