Eur J Clin Pharmacol (2017) 73:1129–1140 DOI 10.1007/s00228-017-2285-4 PHARMACOKINETICS AND DISPOSITION Steady-state pharmacokinetics of mycophenolic acid in renal transplant patients: exploratory analysis of the effects of cyclosporine, recipients’ and donors’ ABCC2 gene variants, and their interactions 1,2 3 4 5 6 7 N. Božina & Z. Lalić & S. Nađ-Škegro & A. Borić-Bilušić & T. Božina & Ž.Kaštelan & V. Trkulja Received: 9 March 2017 /Accepted: 9 June 2017 /Published online: 18 June 2017 Springer-Verlag GmbH Germany 2017 Abstract did not reflect on MPA disposition. However, A-allele at Purpose The study aims to evaluate the impact of recipients’ 1249G>A + CsA (compared to wild type + TAC) was associ- and donors’ polymorphisms in multidrug resistance- ated with a numerically greater increase in MPA clearance (59 associated protein 2 (MRP2) gene ABCC2 -24C>T and vs. 41%), reduction in total exposure (36 vs. 27%) and in- 1249G>A on disposition of mycophenolic acid (MPA) and crease in absorption rate (C /AUC) (56 vs. 37%) than ob- max their interaction with cyclosporine (CsA) (compared to tacro- served for the main effect of CsA. Less pronounced effects limus, TAC) in stable de novo adult renal transplant patients of were observed for the combination of
European Journal of Clinical Pharmacology – Springer Journals
Published: Jun 18, 2017
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera