Steady-state pharmacokinetics of mycophenolic acid in renal transplant patients: exploratory analysis of the effects of cyclosporine, recipients’ and donors’ ABCC2 gene variants, and their interactions

Steady-state pharmacokinetics of mycophenolic acid in renal transplant patients: exploratory... Eur J Clin Pharmacol (2017) 73:1129–1140 DOI 10.1007/s00228-017-2285-4 PHARMACOKINETICS AND DISPOSITION Steady-state pharmacokinetics of mycophenolic acid in renal transplant patients: exploratory analysis of the effects of cyclosporine, recipients’ and donors’ ABCC2 gene variants, and their interactions 1,2 3 4 5 6 7 N. Božina & Z. Lalić & S. Nađ-Škegro & A. Borić-Bilušić & T. Božina & Ž.Kaštelan & V. Trkulja Received: 9 March 2017 /Accepted: 9 June 2017 /Published online: 18 June 2017 Springer-Verlag GmbH Germany 2017 Abstract did not reflect on MPA disposition. However, A-allele at Purpose The study aims to evaluate the impact of recipients’ 1249G>A + CsA (compared to wild type + TAC) was associ- and donors’ polymorphisms in multidrug resistance- ated with a numerically greater increase in MPA clearance (59 associated protein 2 (MRP2) gene ABCC2 -24C>T and vs. 41%), reduction in total exposure (36 vs. 27%) and in- 1249G>A on disposition of mycophenolic acid (MPA) and crease in absorption rate (C /AUC) (56 vs. 37%) than ob- max their interaction with cyclosporine (CsA) (compared to tacro- served for the main effect of CsA. Less pronounced effects limus, TAC) in stable de novo adult renal transplant patients of were observed for the combination of http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png European Journal of Clinical Pharmacology Springer Journals

Steady-state pharmacokinetics of mycophenolic acid in renal transplant patients: exploratory analysis of the effects of cyclosporine, recipients’ and donors’ ABCC2 gene variants, and their interactions

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Publisher
Springer Berlin Heidelberg
Copyright
Copyright © 2017 by Springer-Verlag GmbH Germany
Subject
Biomedicine; Pharmacology/Toxicology
ISSN
0031-6970
eISSN
1432-1041
D.O.I.
10.1007/s00228-017-2285-4
Publisher site
See Article on Publisher Site

Abstract

Eur J Clin Pharmacol (2017) 73:1129–1140 DOI 10.1007/s00228-017-2285-4 PHARMACOKINETICS AND DISPOSITION Steady-state pharmacokinetics of mycophenolic acid in renal transplant patients: exploratory analysis of the effects of cyclosporine, recipients’ and donors’ ABCC2 gene variants, and their interactions 1,2 3 4 5 6 7 N. Božina & Z. Lalić & S. Nađ-Škegro & A. Borić-Bilušić & T. Božina & Ž.Kaštelan & V. Trkulja Received: 9 March 2017 /Accepted: 9 June 2017 /Published online: 18 June 2017 Springer-Verlag GmbH Germany 2017 Abstract did not reflect on MPA disposition. However, A-allele at Purpose The study aims to evaluate the impact of recipients’ 1249G>A + CsA (compared to wild type + TAC) was associ- and donors’ polymorphisms in multidrug resistance- ated with a numerically greater increase in MPA clearance (59 associated protein 2 (MRP2) gene ABCC2 -24C>T and vs. 41%), reduction in total exposure (36 vs. 27%) and in- 1249G>A on disposition of mycophenolic acid (MPA) and crease in absorption rate (C /AUC) (56 vs. 37%) than ob- max their interaction with cyclosporine (CsA) (compared to tacro- served for the main effect of CsA. Less pronounced effects limus, TAC) in stable de novo adult renal transplant patients of were observed for the combination of

Journal

European Journal of Clinical PharmacologySpringer Journals

Published: Jun 18, 2017

References

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