Access the full text.
Sign up today, get DeepDyve free for 14 days.
I. Reid, W. Hague, J. Emberson, J. Baker, A. Tonkin, D. Hunt, S. MacMahon, N. Sharpe (2001)
Effect of pravastatin on frequency of fracture in the LIPID study: secondary analysis of a randomised controlled trial. Long-term Intervention with Pravastatin in Ischaemic Disease.Lancet, 357 9255
I. Reid, W. Hague, J. Emberson, J. Baker, A. Tonkin, D. Hunt, S. MacMahon, N. Sharpe (2001)
Effect of pravastatin on frequency of fracture in the LIPID study: secondly analysis of a randomised controlled trialThe Lancet, 357
J. Peña, S. Aspberg, Jean Macfadyen, R. Glynn, D. Solomon, P. Ridker (2015)
Statin therapy and risk of fracture: results from the JUPITER randomized clinical trial.JAMA internal medicine, 175 2
C. Dormuth, A. Patrick, W. Shrank, J. Wright, R. Glynn, J. Sutherland, M. Brookhart (2009)
Statin Adherence and Risk of Accidents: A Cautionary TaleCirculation, 119
L. Rejnmark, Henrik Buus, P. Vestergaard, L. Heickendorff, F. Andreasen, L. Larsen, L. Mosekilde (2004)
Effects of Simvastatin on Bone Turnover and BMD: A 1‐Year Randomized Controlled Trial in Postmenopausal Osteopenic WomenJournal of Bone and Mineral Research, 19
Zhi-guo Chen, Hua-jie Cai, Xian Jin, Jin-hua Lu, Jing Wang, Ning-yuan Fang (2014)
Effects of atorvastatin on bone mineral density (BMD) and bone metabolism in elderly males with osteopenia and mild dyslipidemia: a 1-year randomized trial.Archives of gerontology and geriatrics, 59 3
Jeffrey Curtis, J. Larson, E. Delzell, M. Brookhart, S. Cadarette, R. Chlebowski, S. Judd, M. Safford, D. Solomon, A. LaCroix (2011)
Placebo Adherence, Clinical Outcomes, and Mortality in the Women's Health Initiative Randomized Hormone Therapy TrialsMedical Care, 49
J. Curtis, E. Delzell, Lang Chen, D. Black, K. Ensrud, S. Judd, M. Safford, A. Schwartz, D. Bauer (2010)
The Relationship Between Bisphosphonate Adherence and Fracture: Is It the Behavior or the Medication? Results From the Placebo Arm of the Fracture Intervention TrialJournal of Bone and Mineral Research, 26
T. An, J. Hao, Sihao Sun, Ruifei Li, M. Yang, Gang Cheng, Meijuan Zou (2016)
Efficacy of statins for osteoporosis: a systematic review and meta-analysisOsteoporosis International, 28
S. Simpson, D. Eurich, S. Majumdar, R. Padwal, R. Tsuyuki, J. Varney, Jeffrey Johnson (2006)
A meta-analysis of the association between adherence to drug therapy and mortalityBMJ : British Medical Journal, 333
Osteoporos Int (2017) 28:2739–2740 DOI 10.1007/s00198-017-4069-1 LETTER Statin use does not protect from fractures: the healthy adherer effect is a plausible explanation in observational studies 1 2 3 A. Donzelli & A. Battaggia & A. Schivalocchi Received: 13 January 2017 /Accepted: 26 April 2017 /Published online: 29 May 2017 The Author(s) 2017. This article is an open access publication Dear Editor, adherence to drug therapy may be a surrogate marker for a The conclusions of the recently published meta-analysis by general healthier behavior. An et al. [1], including 23 observational studies and 10 ran- Famous RCTs showed better outcomes in groups with a domized controlled trials (RCTs), are as follows: Bstatin treat- good adherence to placebo, e.g., in WHI [3], comparing hor- monal replacement therapy versus placebo in postmenopausal ment may be associated with a decreased risk of overall and hip fractures, an increased BMD at the total hip, at the lumbar women, high-adherers in the placebo arm showed significant spine, and OC.^ favorable outcomes, including fewer hip fractures (HR 0.50; We disagree with these conclusions, for the following 95% CI 0.33–0.78) and a decrease in mortality (HR 0.64; reasons. 0.51–0.80) [3], after adjusting for potential confounders. First, observational
Osteoporosis International – Springer Journals
Published: May 29, 2017
Access the full text.
Sign up today, get DeepDyve free for 14 days.