Osteoporos Int (2017) 28:2739–2740 DOI 10.1007/s00198-017-4069-1 LETTER Statin use does not protect from fractures: the healthy adherer effect is a plausible explanation in observational studies 1 2 3 A. Donzelli & A. Battaggia & A. Schivalocchi Received: 13 January 2017 /Accepted: 26 April 2017 /Published online: 29 May 2017 The Author(s) 2017. This article is an open access publication Dear Editor, adherence to drug therapy may be a surrogate marker for a The conclusions of the recently published meta-analysis by general healthier behavior. An et al. , including 23 observational studies and 10 ran- Famous RCTs showed better outcomes in groups with a domized controlled trials (RCTs), are as follows: Bstatin treat- good adherence to placebo, e.g., in WHI , comparing hor- monal replacement therapy versus placebo in postmenopausal ment may be associated with a decreased risk of overall and hip fractures, an increased BMD at the total hip, at the lumbar women, high-adherers in the placebo arm showed significant spine, and OC.^ favorable outcomes, including fewer hip fractures (HR 0.50; We disagree with these conclusions, for the following 95% CI 0.33–0.78) and a decrease in mortality (HR 0.64; reasons. 0.51–0.80) , after adjusting for potential confounders. First, observational
Osteoporosis International – Springer Journals
Published: May 29, 2017
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera