State-dependent Block of Human Cardiac hNav1.5 Sodium Channels by Propafenone

State-dependent Block of Human Cardiac hNav1.5 Sodium Channels by Propafenone State-dependent blockade of human cardiac hNav1.5 sodium channels by propafenone was studied using whole-cell patch clamp techniques. Both a direct investigation using cells with inactivation-deficient sodium channels and an algorithmic approach used on cells with wild-type channels revealed a rapid binding of propafenone to the open state. This occurs approximately 4000 and 700 times faster than the binding to the resting and inactivated state, respectively. An established mathematical “gating” model was modified to represent the experimental data. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png The Journal of Membrane Biology Springer Journals

State-dependent Block of Human Cardiac hNav1.5 Sodium Channels by Propafenone

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Publisher
Springer Journals
Copyright
Copyright © 2005 by Springer Science+Business Media, Inc.
Subject
Life Sciences; Human Physiology; Biochemistry, general
ISSN
0022-2631
eISSN
1432-1424
D.O.I.
10.1007/s00232-005-0801-4
Publisher site
See Article on Publisher Site

Abstract

State-dependent blockade of human cardiac hNav1.5 sodium channels by propafenone was studied using whole-cell patch clamp techniques. Both a direct investigation using cells with inactivation-deficient sodium channels and an algorithmic approach used on cells with wild-type channels revealed a rapid binding of propafenone to the open state. This occurs approximately 4000 and 700 times faster than the binding to the resting and inactivated state, respectively. An established mathematical “gating” model was modified to represent the experimental data.

Journal

The Journal of Membrane BiologySpringer Journals

Published: Jan 1, 2005

References

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