Ann Surg Oncol (2017) 24:2556–2562 DOI 10.1245/s10434-017-5898-z OR IG INA L A R TIC L E – BREA S T O NC OLOG Y Standard Pathologic Features Can Be Used to Identify a Subset of Estrogen Receptor-Positive, HER2 Negative Patients Likely to Beneﬁt from Neoadjuvant Chemotherapy 1 1 2 1 Oriana A. Petruolo, MD , Melissa Pilewskie, MD , Sujata Patil, PhD , Andrea V. Barrio, MD , Michelle Stempel, 1 3 1 MPH , Hannah Y. Wen, MD, PhD , and Monica Morrow, MD 1 2 Breast Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY ; Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY ABSTRACT axilla, nodal pCR among cN? patients (n = 301) ranged Background. The beneﬁt of neoadjuvant chemotherapy from 0 to 35% (p \ 0.0001) within these groups, and was (NAC) in patients with estrogen receptor-positive (ER?)/ most frequent in PR-/HP patients. human epidermal growth factor receptor 2-negative Conclusions. ER?/HER2- patients most likely to beneﬁt (HER2-) breast cancers and in invasive lobular carcinoma from NAC are those with PR- and HP tumors. Patients (ILC) is
Annals of Surgical Oncology – Springer Journals
Published: May 30, 2017
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