Standard Pathologic Features Can Be Used to Identify a Subset of Estrogen Receptor-Positive, HER2 Negative Patients Likely to Benefit from Neoadjuvant Chemotherapy

Standard Pathologic Features Can Be Used to Identify a Subset of Estrogen Receptor-Positive, HER2... Ann Surg Oncol (2017) 24:2556–2562 DOI 10.1245/s10434-017-5898-z OR IG INA L A R TIC L E – BREA S T O NC OLOG Y Standard Pathologic Features Can Be Used to Identify a Subset of Estrogen Receptor-Positive, HER2 Negative Patients Likely to Benefit from Neoadjuvant Chemotherapy 1 1 2 1 Oriana A. Petruolo, MD , Melissa Pilewskie, MD , Sujata Patil, PhD , Andrea V. Barrio, MD , Michelle Stempel, 1 3 1 MPH , Hannah Y. Wen, MD, PhD , and Monica Morrow, MD 1 2 Breast Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY ; Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY ABSTRACT axilla, nodal pCR among cN? patients (n = 301) ranged Background. The benefit of neoadjuvant chemotherapy from 0 to 35% (p \ 0.0001) within these groups, and was (NAC) in patients with estrogen receptor-positive (ER?)/ most frequent in PR-/HP patients. human epidermal growth factor receptor 2-negative Conclusions. ER?/HER2- patients most likely to benefit (HER2-) breast cancers and in invasive lobular carcinoma from NAC are those with PR- and HP tumors. Patients (ILC) is http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annals of Surgical Oncology Springer Journals

Standard Pathologic Features Can Be Used to Identify a Subset of Estrogen Receptor-Positive, HER2 Negative Patients Likely to Benefit from Neoadjuvant Chemotherapy

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Publisher
Springer International Publishing
Copyright
Copyright © 2017 by Society of Surgical Oncology
Subject
Medicine & Public Health; Surgical Oncology; Oncology; Surgery
ISSN
1068-9265
eISSN
1534-4681
D.O.I.
10.1245/s10434-017-5898-z
Publisher site
See Article on Publisher Site

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