Short Communications ellOllle Mammalian Genome 8, 441-442 (1997). 9 Springer-Verlag New York Inc. 1997 SSLPs to map genetic differences between the 129 inbred strains and closed-colony, random-bred CD-1 mice David W. Thread~ill, 1'2 Aragabin Matin, 2 Della Yee, 2 Minerva M. Carrasquillo, 2 Kenneth R. Henry, z Karen G. Rollins," Joseph H. Nadeau, 2 Terry Magnuson 2 ~Department of Cell Biology, Vanderbilt University School of Medicine, 1161 21 st Ave. S, Nashville, TN 37232, USA 2Department of Genetics, Case Western Reserve University School of Medicine, 10900 Euclid Ave., Cleveland, OH 44106, USA Received: 2 December 1996 / Accepted: 10 February 1997 Gene targeting is an important tool for analyzing gene function in tween an inbred 129/Sv-+ ryr +P substrain and a closed, random- vivo as well as a means for creating animal models for specific breeding CD-1 colony. We found 290 SSLPs spanning all 19 human diseases. Additionally, numerous targeted loci show phe- autosomes and the X Chromosome (Chr) that show differences notypes that depend on genetic background, thus providing an between 129/Sv-+ ryr +P and CD-1. We also typed the 129/SvJ even broader understanding of gene function (Threadgill et al. (129cX/Sv), 129/J, and 129/Ola substrains at 212 SSLPs
Mammalian Genome – Springer Journals
Published: Mar 24, 2009
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