Ann Surg Oncol (2017) 24:2603–2610 DOI 10.1245/s10434-017-5946-8 O R I G IN AL ARTI CL E – EN DO CRIN E T UM ORS Sporadic Small (£20 mm) Nonfunctioning Pancreatic Neuroendocrine Neoplasm: is the Risk of Malignancy Negligible When Adopting a More Conservative Strategy? A Systematic Review and Meta-analysis 1 1 1 1 Claudio Ricci, MD , Riccardo Casadei, MD , Giovanni Taffurelli, MD , Carlo Alberto Pacilio, MD , 1 2 2 1 Davide Campana, MD , Valentina Ambrosini, MD , Santini Donatella, MD , and Francesco Minni, MD Department of Internal Medicine and Surgery (DIMEC), Chirurgia Generale-Minni, Alma Mater Studiorum-Universita ` di Bologna, Bologna, Italy; Department of Specialized Diagnostic and Experimental Medicine (DIMES), Bologna, Italy ABSTRACT times higher than the beneﬁts. The risk difference of distant Background. The management of small (B20 mm), non- metastases, G3 lesions, G2–G3 lesions, stage III/IV, functioning pancreatic neuroendocrine neoplasms (pNENs) microscopic vascular invasion, death, and recurrence of the remains under debate. The European Neuroendocrine disease were lower in small NF-PNETs than large ones. Tumor Society guidelines advocate the possibility of a The related LHH values suggested that a watch-and-wait conservative approach. policy never provided a beneﬁt. Methods. A systematic literature search
Annals of Surgical Oncology – Springer Journals
Published: Jul 5, 2017
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