Sporadic Creutzfeldt-Jakob disease presenting with isolated progressive non-fluent aphasia in a young woman

Sporadic Creutzfeldt-Jakob disease presenting with isolated progressive non-fluent aphasia in a... Neurol Sci (2017) 38:1535–1537 DOI 10.1007/s10072-017-2968-8 LETTER TO THE EDITOR Sporadic Creutzfeldt-Jakob disease presenting with isolated progressive non-fluent aphasia in a young woman 1 1 2 1 Alberto Terrin & Andrea Barp & Gianluigi Zanusso & Paolo Gallo & Annachiara Cagnin Received: 20 February 2017 /Accepted: 18 April 2017 /Published online: 25 April 2017 Springer-Verlag Italia 2017 Introduction Probable sCJD was diagnosed in vivo with detection of prion protein (PrP) seeding activity through Real-Time Quaking- Creutzfeldt-Jakob disease (CJD) belongs to a family of neu- Induced Conversion (RT-QuIC) in CSF and olfactory mucosa rodegenerative diseases known as transmissible spongiform (OM) samples. encephalopathies or prion diseases. Sporadic (sCJD), the most common form, occurs at an incidence of 1/100.0000/year. Onset usually occurs in the seventh decade of life, and life Case report expectancy is about 5 months. Clinically, sCJD is character- ized by a rapidly progressive dementia, myoclonus, visual, or A 47-year-old woman was admitted to the Neurological cerebellar disturbances, pyramidal or extrapyramidal signs, Clinic, Department of Neurosciences, in Padova (Italy) for and akinetic mutism [1]. Brain MRI can support the clinical rapidly progressive language impairment in the previous diagnosis of sCJD showing signal hyperintensity at the month. At admission, neurological evaluation http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Neurological Sciences Springer Journals

Sporadic Creutzfeldt-Jakob disease presenting with isolated progressive non-fluent aphasia in a young woman

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Publisher
Springer Milan
Copyright
Copyright © 2017 by Springer-Verlag Italia
Subject
Medicine & Public Health; Neurology; Neuroradiology; Neurosurgery; Psychiatry
ISSN
1590-1874
eISSN
1590-3478
D.O.I.
10.1007/s10072-017-2968-8
Publisher site
See Article on Publisher Site

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