Spontaneously Opening GABAA Channels in CA1 Pyramidal Neurones of Rat Hippocampus

Spontaneously Opening GABAA Channels in CA1 Pyramidal Neurones of Rat Hippocampus Spontaneous, single channel, chloride currents were recorded in 48% of cell-attached patches on neurones in the CA1 region of rat hippocampal slices. In some patches, there was more than 1 channel active. They showed outward rectification: both channel conductance and open probability were greater at depolarized than at hyperpolarized potentials. Channels activated by γ-aminobutyric acid (GABA) in silent patches on the same neurones had similar conductance and outward rectification. The spontaneous currents were inhibited by bicuculline and potentiated by diazepam. It was concluded that the spontaneously opening channels were constitutively active, nonsynaptic GABAA channels. Such spontaneously opening GABAA channels may provide a tonic inhibitory mechanism in these cells and perhaps in other cells that have GABAA receptors although not having a GABAA synaptic input. They may also be a target for clinically useful drugs such as the benzodiazepines. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png The Journal of Membrane Biology Springer Journals

Spontaneously Opening GABAA Channels in CA1 Pyramidal Neurones of Rat Hippocampus

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Publisher
Springer-Verlag
Copyright
Copyright © Inc. by 2000 Springer-Verlag New York
Subject
Life Sciences; Biochemistry, general; Human Physiology
ISSN
0022-2631
eISSN
1432-1424
D.O.I.
10.1007/s002320001028
Publisher site
See Article on Publisher Site

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