Short Communications Incorporating Mouse Genome Mammalian Genome 11, 231–233 (2000). © Springer-Verlag New York Inc. 2000 Sox14 maps to mouse Chromosome 9 and shows no mutations in the neurological mouse mutants ducky and tippy Murray Hargrave, Kristy James, Toshiya Yamada, Peter Koopman Centre for Molecular and Cellular Biology, The University of Queensland, Brisbane, Queensland 4072, Australia Received: 19 July 1999 / Accepted: 29 October 1999 Sox genes are members of a large and well-conserved gene family TaqI restriction digestion produced two fragments of 275 bp and 107 bp, while DNA amplified from M. spretus remained uncut. and encode transcription factors characterized by a DNA-binding This PCR reaction and digestion were used to screen for each motif termed the HMG domain. A large body of work has dem- allele in DNA from 50 random EUCIB backcross mice. Haplotype onstrated that Sox genes have many diverse functions in the de- analysis localized Sox14 to distal mouse Chr 9 between the anony- velopment of animals (Wegner 1999). Further, orthologous Sox mous anchor loci D9Nds8 and D9Mit24. One of the mice (LB199) genes show high conservation of structure and expression among showed a double recombination event between these markers and vertebrate species, suggesting
Mammalian Genome – Springer Journals
Published: Feb 26, 2014
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