Mammalian Genome 8, 773–774 (1997). © Springer-Verlag New York Inc. 1997 Somatic cell mapping of the adenine nucleotide translocator gene family in cattle Lei Li, James E. Womack Department of Veterinary Pathobiology, Texas A&M University, College Station, TX 77843, USA Received: 17 March 1996 / Accepted: 25 May 1997 Table 1. Concordancy analysis (%) of ANT family with chromosomes. Adenine nucleotide translocator [ADP/ATP translocase, (ANT), or ADP/ATP carrier, (AAC)] is the most abundant mitochondrial Chromosomes ANT1 ANT2 ANT3 protein. As an integral component of the inner mitochondrial mem- brane, it catalyzes the exchange of intramitochondrial ATP for 1 701010 2 604040 cytoplasmic ADP, consequently controlling the ATP supply of the 3 602020 cell (Klingenberg 1989). Its central role in cellular energy supply 4 604040 suggests that ANT might be regulated in different tissues to fit 5 355555 tissue-specific functional and development requirements. Tissue 6 652525 7 503030 specificity of bovine ANT activity was first evidenced in immu- 8 456565 nological studies (Schultheiss and Klingenberg 1984), and subse- 9 325858 quently three functional ANT genes and seven pseudogenes have 10 45 65 65 11 50 60 60 been identified in the human genome (Chen et al. 1990; Houlds- 12 40
Mammalian Genome – Springer Journals
Published: Oct 1, 1997
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