Res Chem Intermed (2015) 41:6749–6763 DOI 10.1007/s11164-014-1774-7 Solvent-free silica-promoted multicomponent condensation: synthesis of highly functionalized piperidines • • Sudarshan Das Avik Kumar Bagdi • • Sougata Santra Adinath Majee Alakananda Hajra Received: 17 June 2014 / Accepted: 23 July 2014 / Published online: 13 August 2014 Springer Science+Business Media Dordrecht 2014 Abstract Silica gel has been found to be an efﬁcient and reusable medium for the synthesis of diastereospeciﬁc functionalized piperidines in good to high yields by a one- pot three-component condensation of aldehyde, amine and b-ketoester under solvent- free conditions at room temperature. Using this environmentally benign, non-inﬂam- mable and non-toxic reaction medium, the non-chromatographic puriﬁcation, reusability of the silica gel, and operational simplicity are the notable advantages of the present method. The procedure is applicable for large-scale synthesis of piperidines derivatives and represents a green synthetic protocol. Keywords Solid-support Solvent-free Multicomponent reaction Diastereoselective Piperidines Silica gel Introduction Organic reactions in heterogeneous medium have proven its usefulness and practicability to chemists in the laboratory as well as in the industrial context. The organic syntheses on supported reagents have recently received considerable attention from synthetic chemists because of their high efﬁciency, environmentally benign conditions, and
Research on Chemical Intermediates – Springer Journals
Published: Aug 13, 2014
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