Solvent-free silica-promoted multicomponent condensation: synthesis of highly functionalized piperidines

Solvent-free silica-promoted multicomponent condensation: synthesis of highly functionalized... Res Chem Intermed (2015) 41:6749–6763 DOI 10.1007/s11164-014-1774-7 Solvent-free silica-promoted multicomponent condensation: synthesis of highly functionalized piperidines • • Sudarshan Das Avik Kumar Bagdi • • Sougata Santra Adinath Majee Alakananda Hajra Received: 17 June 2014 / Accepted: 23 July 2014 / Published online: 13 August 2014 Springer Science+Business Media Dordrecht 2014 Abstract Silica gel has been found to be an efficient and reusable medium for the synthesis of diastereospecific functionalized piperidines in good to high yields by a one- pot three-component condensation of aldehyde, amine and b-ketoester under solvent- free conditions at room temperature. Using this environmentally benign, non-inflam- mable and non-toxic reaction medium, the non-chromatographic purification, reusability of the silica gel, and operational simplicity are the notable advantages of the present method. The procedure is applicable for large-scale synthesis of piperidines derivatives and represents a green synthetic protocol. Keywords Solid-support  Solvent-free  Multicomponent reaction Diastereoselective  Piperidines  Silica gel Introduction Organic reactions in heterogeneous medium have proven its usefulness and practicability to chemists in the laboratory as well as in the industrial context. The organic syntheses on supported reagents have recently received considerable attention from synthetic chemists because of their high efficiency, environmentally benign conditions, and http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Research on Chemical Intermediates Springer Journals

Solvent-free silica-promoted multicomponent condensation: synthesis of highly functionalized piperidines

Loading next page...
 
/lp/springer_journal/solvent-free-silica-promoted-multicomponent-condensation-synthesis-of-QAvyNOYF3z
Publisher
Springer Netherlands
Copyright
Copyright © 2014 by Springer Science+Business Media Dordrecht
Subject
Chemistry; Catalysis; Physical Chemistry; Inorganic Chemistry
ISSN
0922-6168
eISSN
1568-5675
D.O.I.
10.1007/s11164-014-1774-7
Publisher site
See Article on Publisher Site

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 12 million articles from more than
10,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Unlimited reading

Read as many articles as you need. Full articles with original layout, charts and figures. Read online, from anywhere.

Stay up to date

Keep up with your field with Personalized Recommendations and Follow Journals to get automatic updates.

Organize your research

It’s easy to organize your research with our built-in tools.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

Monthly Plan

  • Read unlimited articles
  • Personalized recommendations
  • No expiration
  • Print 20 pages per month
  • 20% off on PDF purchases
  • Organize your research
  • Get updates on your journals and topic searches

$49/month

Start Free Trial

14-day Free Trial

Best Deal — 39% off

Annual Plan

  • All the features of the Professional Plan, but for 39% off!
  • Billed annually
  • No expiration
  • For the normal price of 10 articles elsewhere, you get one full year of unlimited access to articles.

$588

$360/year

billed annually
Start Free Trial

14-day Free Trial