Solubility and Stability of Proroxan at Various PH Values

Solubility and Stability of Proroxan at Various PH Values DOI 10.1007/s11094-018-1798-1 Pharmaceutical Chemistry Journal, Vol. 52, No. 3, June, 2018 (Russian Original Vol. 52, No. 3, March, 2018) SOLUBILITY AND STABILITY OF PROROXAN AT VARIOUS PH VALUES 1,* 1 1 S. P. Krechetov, G. O. Nifontova, O. V. Dolotova, and M. S. Veselov Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 52, No. 3, pp. 41 – 45, March, 2018. Original article submitted April 26, 2017. The solubility and stability of the nonselective -adrenoblocker 1-(2,3-dihydro-1,4-benzdioxin-6-yl)-3-(3- phenyl-1-pyrrolidinyl)-1-propanone hydrochloride (proroxan) at various pH values were investigated. It was established that proroxan solubility was reduced for 3 < pH < 5.5, which corresponded to the protonated spe- cies; was uncharacteristic for salts of organic bases; and increased its destruction. It was suggested that this pe- culiarity of proroxan behavior in aqueous solutions could reflect complexation between its protonated and unprotonated molecules. The results indicated that proroxan preparations using dosage forms and delivery systems that provide its maximum absorption in the stomach must be developed. Keywords: proroxan, solubility, stability, pH. Use of pharmaceutical substances (PSs) with clinically EXPERIMENTAL PART proven efficacy in modified-release dosage forms is a current PS proroxan was obtained from Chemical Line Co. Ltd. thrust in new drug design [1]. Use of http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Pharmaceutical Chemistry Journal Springer Journals

Solubility and Stability of Proroxan at Various PH Values

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Publisher
Springer US
Copyright
Copyright © 2018 by Springer Science+Business Media, LLC, part of Springer Nature
Subject
Pharmacy; Pharmacy; Pharmacology/Toxicology; Organic Chemistry
ISSN
0091-150X
eISSN
1573-9031
D.O.I.
10.1007/s11094-018-1798-1
Publisher site
See Article on Publisher Site

Abstract

DOI 10.1007/s11094-018-1798-1 Pharmaceutical Chemistry Journal, Vol. 52, No. 3, June, 2018 (Russian Original Vol. 52, No. 3, March, 2018) SOLUBILITY AND STABILITY OF PROROXAN AT VARIOUS PH VALUES 1,* 1 1 S. P. Krechetov, G. O. Nifontova, O. V. Dolotova, and M. S. Veselov Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 52, No. 3, pp. 41 – 45, March, 2018. Original article submitted April 26, 2017. The solubility and stability of the nonselective -adrenoblocker 1-(2,3-dihydro-1,4-benzdioxin-6-yl)-3-(3- phenyl-1-pyrrolidinyl)-1-propanone hydrochloride (proroxan) at various pH values were investigated. It was established that proroxan solubility was reduced for 3 < pH < 5.5, which corresponded to the protonated spe- cies; was uncharacteristic for salts of organic bases; and increased its destruction. It was suggested that this pe- culiarity of proroxan behavior in aqueous solutions could reflect complexation between its protonated and unprotonated molecules. The results indicated that proroxan preparations using dosage forms and delivery systems that provide its maximum absorption in the stomach must be developed. Keywords: proroxan, solubility, stability, pH. Use of pharmaceutical substances (PSs) with clinically EXPERIMENTAL PART proven efficacy in modified-release dosage forms is a current PS proroxan was obtained from Chemical Line Co. Ltd. thrust in new drug design [1]. Use of

Journal

Pharmaceutical Chemistry JournalSpringer Journals

Published: Jun 2, 2018

References

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