J. Membrane Biol. 161, 105–113 (1998) The Journal of Membrane Biology © Springer-Verlag New York Inc. 1998 Topical Review Slow Changes in the Availability of Voltage-gated Ion Channels: Effects on the Dynamics of Excitable Membranes S. Marom The Sir Bernard Katz Minerva Center for Cell Biophysics and the Rappaport Institute for Research in the Medical Sciences, Faculty of Medicine, Technion, Haifa 31096, Israel Received: 16 June 1997/Revised: 31 July 1997 Introduction conducted a series of studies aimed at uncovering the relations between the ionic environments, membrane Excitability stands at the basis of many physiological conductance, fluxes and voltage changes in excitable systems (e.g., neural systems, cardiac cells, hormone- membranes (for an interesting overview of these ‘heroic’ releasing cell clusters). In most cases, the action poten- times see Hodgkin, 1992). Their efforts led to the el- tial (the excitation event itself) operates on a relatively egant and symmetrical mathematical model of Hodgkin fast time scale, whereas the system is modulated at time and Huxley (1952) which accounts for conduction and scales that are many orders of magnitude slower. The excitation in quantitative terms. The impact of the search for mechanisms to bridge this time gap usually Hodgkin-Huxley model was so
The Journal of Membrane Biology – Springer Journals
Published: Jan 15, 1998
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