Sleep and Dementia

Sleep and Dementia Purpose of Review In this review, we seek to analyze the most novel findings recently published in the literature on sleep and dementia. Recent Findings The degeneration of suprachiasmatic nucleus and prefrontal cortex in dementia disrupts sleep-wake rhythmicity and contributes to cognitive deterioration in Alzheimer’s Dementia (AD), respectively. Sleep deprivation increases amyloid-β production and decreases its clearance. Short and long duration of sleep increase risk of cognitive disorders. Studies suggest that obstructive sleep apnea accelerates amyloid deposition though intermittent hypoxia. Effect of CPAP on cognition is controversial. Subjects with severe daytime sleepiness or sleep-related movement disorder have a higher risk for vascular dementia. Summary These findings highlight the impact of sleep on dementia. Thus, the bi-directional link of sleep and neurodegenerative disease may influence each other in many ways that have important implications for the diagnosis and treatment of AD. . . . . . Keywords Sleep Dementia Obstructive sleep apnea Cognitive decline Insomnia REM behavior disorder Introduction appropriate, additional references will be made to the other types of dementias. Dementia is usually caused by neurodegenerative diseases Dementia is characterized by progressive loss of cognition, memory, emotions, and behavior [1]. The prevalence of AD such as Alzheimer’s disease (AD), http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Sleep Medicine Reports Springer Journals

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Publisher
Springer Journals
Copyright
Copyright © 2018 by Springer International Publishing AG, part of Springer Nature
Subject
Medicine & Public Health; Internal Medicine; General Practice / Family Medicine; Otorhinolaryngology; Neurology; Cardiology; Psychiatry
eISSN
2198-6401
D.O.I.
10.1007/s40675-018-0112-9
Publisher site
See Article on Publisher Site

Abstract

Purpose of Review In this review, we seek to analyze the most novel findings recently published in the literature on sleep and dementia. Recent Findings The degeneration of suprachiasmatic nucleus and prefrontal cortex in dementia disrupts sleep-wake rhythmicity and contributes to cognitive deterioration in Alzheimer’s Dementia (AD), respectively. Sleep deprivation increases amyloid-β production and decreases its clearance. Short and long duration of sleep increase risk of cognitive disorders. Studies suggest that obstructive sleep apnea accelerates amyloid deposition though intermittent hypoxia. Effect of CPAP on cognition is controversial. Subjects with severe daytime sleepiness or sleep-related movement disorder have a higher risk for vascular dementia. Summary These findings highlight the impact of sleep on dementia. Thus, the bi-directional link of sleep and neurodegenerative disease may influence each other in many ways that have important implications for the diagnosis and treatment of AD. . . . . . Keywords Sleep Dementia Obstructive sleep apnea Cognitive decline Insomnia REM behavior disorder Introduction appropriate, additional references will be made to the other types of dementias. Dementia is usually caused by neurodegenerative diseases Dementia is characterized by progressive loss of cognition, memory, emotions, and behavior [1]. The prevalence of AD such as Alzheimer’s disease (AD),

Journal

Current Sleep Medicine ReportsSpringer Journals

Published: May 21, 2018

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