Sitagliptin add-on therapy cost saving for T2DM in Italy

Sitagliptin add-on therapy cost saving for T2DM in Italy PharmacoEconomics & Outcomes News 792, p28 - 2 Dec 2017 Sitagliptin add-on therapy cost saving for T2DM in Italy Sitagliptin added on to metformin is a cost-saving alternative to sulfonylurea add-on therapy for the management of patients with type 2 diabetes mellitus (T2DM) in Italy. This is the main finding of a cost-consequence analysis conducted to assess the economic impact of using sitagliptin, compared with sulfonylureas, as second-line therapy in add-on to metformin for a hypothetical cohort of 100 000 patients with T2DM not achieving glycaemic control with metformin monotherapy. The analysis was conducted from the Italian National Health Service (INHS) and a societal perspective. The data analysis showed that use of sitagliptin as add-on to metformin was cost saving from both the INHS and a societal perspective, generating savings of €51 846 442 and €61 217 723, respectively, over a 3-year time horizon. The researchers note that the higher drug acquisition costs related to sitagliptin + metformin therapy (€83 387 970) were offset by other costs for disease management at 3 years of follow-up, in particular due to lower use of devices for blood glucose self-monitoring, a lower incidence of hypoglycaemia and cardiovascular (CV) events, and a delay to insulin switch. The analysis also showed that use of sitagliptin would avoid 26 882 non-severe hypoglycaemic events, 6528 severe hypoglycaemic events and 1562 major CV events. * The study was supported by Merck Sharp & Dohme. Lorenzoni V, et al. Cost-consequence analysis of sitagliptin versus sulfonylureas as add-on therapy for the treatment of diabetic patients in Italy. ClinicoEconomics and Outcomes Research : 20 Nov 2017. Available from: URL: https:// doi.org/10.2147/CEOR.S141477 803285955 1173-5503/17/0792-0001/$14.95 Adis © 2017 Springer International Publishing AG. All rights reserved PharmacoEconomics & Outcomes News 2 Dec 2017 No. 792 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png PharmacoEconomics & Outcomes News Springer Journals

Sitagliptin add-on therapy cost saving for T2DM in Italy

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Publisher
Springer International Publishing
Copyright
Copyright © 2017 by Springer International Publishing AG, part of Springer Nature
Subject
Medicine & Public Health; Pharmacoeconomics and Health Outcomes; Quality of Life Research; Health Economics; Public Health
ISSN
1173-5503
eISSN
1179-2043
D.O.I.
10.1007/s40274-017-4551-1
Publisher site
See Article on Publisher Site

Abstract

PharmacoEconomics & Outcomes News 792, p28 - 2 Dec 2017 Sitagliptin add-on therapy cost saving for T2DM in Italy Sitagliptin added on to metformin is a cost-saving alternative to sulfonylurea add-on therapy for the management of patients with type 2 diabetes mellitus (T2DM) in Italy. This is the main finding of a cost-consequence analysis conducted to assess the economic impact of using sitagliptin, compared with sulfonylureas, as second-line therapy in add-on to metformin for a hypothetical cohort of 100 000 patients with T2DM not achieving glycaemic control with metformin monotherapy. The analysis was conducted from the Italian National Health Service (INHS) and a societal perspective. The data analysis showed that use of sitagliptin as add-on to metformin was cost saving from both the INHS and a societal perspective, generating savings of €51 846 442 and €61 217 723, respectively, over a 3-year time horizon. The researchers note that the higher drug acquisition costs related to sitagliptin + metformin therapy (€83 387 970) were offset by other costs for disease management at 3 years of follow-up, in particular due to lower use of devices for blood glucose self-monitoring, a lower incidence of hypoglycaemia and cardiovascular (CV) events, and a delay to insulin switch. The analysis also showed that use of sitagliptin would avoid 26 882 non-severe hypoglycaemic events, 6528 severe hypoglycaemic events and 1562 major CV events. * The study was supported by Merck Sharp & Dohme. Lorenzoni V, et al. Cost-consequence analysis of sitagliptin versus sulfonylureas as add-on therapy for the treatment of diabetic patients in Italy. ClinicoEconomics and Outcomes Research : 20 Nov 2017. Available from: URL: https:// doi.org/10.2147/CEOR.S141477 803285955 1173-5503/17/0792-0001/$14.95 Adis © 2017 Springer International Publishing AG. All rights reserved PharmacoEconomics & Outcomes News 2 Dec 2017 No. 792

Journal

PharmacoEconomics & Outcomes NewsSpringer Journals

Published: Dec 2, 2017

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